Iodotyrosine

Iodotyrosine is the general name for iodinated tyrosine derivatives (mono- and diiodotyrosine), which are precursors of thyroid hormones. The determination of iodotyrosine is important in the diagnosis and study of the pathogenesis of various thyroid diseases.

Moniodotyrosine and diiodotyrosine are formed in the follicular cells of the thyroid gland by iodination of the amino acid tyrosine. Next, triiodothyronine (T3) and thyroxine (T4) - the main thyroid hormones - are synthesized from these compounds.

Determining the level of iodotyrosine in the blood, urine or thyroid tissue allows us to evaluate the processes of tyrosine iodization and hormone synthesis in the gland. Elevated levels of iodotyrosine may indicate impaired synthesis or secretion of thyroid hormones in diseases of the thyroid gland. Thus, analysis for iodotyrosine is used to diagnose and study the mechanisms of development of thyroid pathology.

Iodotyrosines are the general name for substances derived from monoiodotyrosine or diodotyrozone by replacing the iodine atom with other non-orbital atoms such as hydrogen, methane or hydrocarbon radicals of 5 to 20 carbon atoms in length. For the first time, monoiodotyrosines were isolated from the thyroid gland (one of the most important organs of the thyroid gland).