Complement C8, Complement C9

Complement C8 and complement C9 are complement components that participate in the formation of the membrane attack complex. After the previous complement components (C5b-7) attach to the target cell membrane, binding of C8 and then C9 occurs. This leads to the polymerization of C9 molecules and the formation of transmembrane channels in the lipid bilayer of the cell membrane. Through these channels, the uncontrolled release of intracellular components begins, which ultimately leads to cell death.

Thus, complement C8 and C9 are the key components responsible for the destruction of cell membranes during the process of complement-mediated lysis. Their fixation on the membrane triggers irreversible changes in the cytoplasmic membrane, leading to its damage and cell death. This mechanism plays an important role in immunity, allowing the elimination of foreign cells.

Complements C8 and C9

Complement is a complex cascade of reactions triggered by the antigen-antibody immune complex and leading to the lysis or activation of host cells during the immune response. This cascade consists of different classes of components, some of which are known as antibodies. Part of the caspase pathway, complement component C5a, is also known as the alternative pathway activator. Let's consider one of the components that secrete this group of proteolytic enzymes - the complement component C8.

C8 (sekin 8) is a component of the coagulation pathway of the cascade hemolysis system - a powerful mechanism of hemolytic tissue damage induced by fever, inflammatory processes, and the development of certain immunopathological conditions. In contrast to the components of coagulation cascades, the branch of which is always accompanied by phagocytosis, caspase C8 is localized primarily in the cell - mediated cell death can be described as apoptotic (nuclear-free), with genetically fixed cytotoxicity.

The main inducer of death as a result of the action of component C6 are cytolytic proteins of tick-borne encephalitis viruses (rabies virus, rickettsia, rubella virus, various herpes viruses), as well as microbial proteins, bacterial enterotoxins,