Neurofibroma Plexiform

Neurofibroma plexiformis: understanding, diagnosis and treatment

Neurofibroma plexiformis, also known as cluster neuroma or ramus neuroma, is a type of neurofibroma, a neuroectodermal tumor that arises from nerve sheath cells. It is a chronic neurofibromatous disease that can have a significant impact on the patient's quality of life. In this article, we will review the basic aspects of neurofibroma plexiformis, including its characteristics, diagnostic methods, and available treatment options.

Neurofibroma plexiformis is characterized by the formation of tumor-like formations along peripheral nerves, which can be grape-shaped and penetrate into surrounding tissues. Tumors are composed of various cell types, including neural, fibrous, and target cells. Neurofibroma plexiformis often occurs in childhood and may continue to develop throughout the patient's life.

Diagnosis of neurofibroma plexiform includes a physical examination, the patient's medical history, and various instrumental studies. Techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) are commonly used to visualize tumor masses and assess their size and location. A biopsy may be performed to confirm the diagnosis and determine the nature of the tumor.

Treatment for neurofibroma plexiformis can be complex and depends on many factors, including the size and location of the tumor, as well as possible symptoms and complications. In some cases, when the tumor is small and does not cause significant problems, a decision may be made to observe without medication or surgery. However, more severe cases may require surgical removal of the tumor or other treatments such as radiotherapy or chemotherapy.

It is important to note that neurofibroma plexiformis is a chronic disease and long-term treatment and observation may be required to monitor the patient's condition. Regular consultations with your doctor and specialists such as neurologists, oncologists and surgeons may be necessary for effective management of the disease.

In conclusion, neurofibroma plexiformis is a serious condition associated with the formation of tumors along peripheral nerves. Diagnosis and treatment of this disease require an integrated approach and mandatory supervision by specialists. Early detection and timely treatment can help improve prognosis and symptom management in patients with neurofibroma plexiformis.

**Pleximorphic neurofibromas (NPPs)** are benign tumors of mesenchymal origin, consisting of proliferating fibroblasts and usually neuralgic cells, with a typical microscopic appearance, which develop under the skin or within the thickness of muscles or fascia. They are diagnosed at any age in the form of nodules of varying sizes from a few millimeters to 5 cm, the color of the skin over which matches or slightly exceeds the color of the surrounding skin (usually with a bluish tint). They are characterized by the multiple appearance of many small inclusions on the skin of the face, body and legs, often forming dermatomes like a bunch or histion (from the ancient Greek histios - skin, blos - plexus); hence their second name - “nest” tumor. Such formations are considered quite common malformations of SNP and, as the name of the disease suggests, appear congenitally. However, the development of tumors in childhood and also in adulthood cannot be ruled out. Such neoplasms produce symptoms when they reach a significant size. At this point, a person may notice the growth of a peripheral node, its enlargement or corroded