Pachycarpine

Pahicarpin: symptoms, treatment and consequences

Pachycarpine is a poison that has a high degree of toxicity and can cause serious disruption in the functioning of the human body. This poison has a selective neurotoxic (ganglionic blocking) effect and can cause severe poisoning.

Stage I of pachycarpine poisoning is characterized by the appearance of nausea, vomiting, abdominal pain, dizziness, weakness and dry mucous membranes. Stage II of poisoning is manifested by impaired neuromuscular conduction, dilated pupils, deterioration of vision and hearing, severe weakness, ataxia, psychomotor agitation, clonic-tonic convulsions, myofibrillations, tachycardia, pallor, acrocyanosis and arterial hypotension. Stage III poisoning can lead to coma, respiratory failure, collapse and cardiac arrest with sudden bradycardia. The lethal dose of pachycarpine is about 2 g.

Treatment of pachycarpine poisoning should begin with gastric lavage through a tube, the use of a saline laxative, forced diuresis, hemodialysis and hemosorption. In the first stage, specific therapy is not carried out. In the second stage, proserin 0.05% solution subcutaneously, ATP (6-8 ml of 1% solution on days 1-2, 2-3 ml on days 3-4) intramuscularly, thiamine can be used (5% solution, 5-30 mg on days 1-2, 5-8 mg on days 3-4) i.v. In the third stage, treatment may include proserin (0.05% solution, 20-30 mg in the first 2 days, 2-6 mg on the 3-4th day), ATP (12-15 ml in the first 2 days, then 2-3 ml of 1% solution), thiamine (5% solution, 15-30 mg in the first 2 days, then 5-8 mg). In case of respiratory arrest, artificial ventilation of the lungs is necessary, and in case of convulsions, diazepam 5-10 mg IV.

Pachycarpine poisoning can cause serious consequences, including problems with the heart, respiratory system, and nervous system, as well as death. Therefore, it is important to know how to prevent poisoning from this poison. It is necessary to monitor the quality and safety of food, avoid consuming unknown and suspicious products, and follow the rules of storage and preparation of food. If poisoning is suspected, do not delay and seek medical help immediately.

It is also important to remember safety rules when working with poisons and hazardous chemicals. It is necessary to comply with all requirements for the storage and use of toxic substances, as well as the rules of personal hygiene and protection.

In conclusion, pachycarpine poisoning can lead to serious consequences and even death. Therefore, it is necessary to take precautions, monitor the quality and safety of food, and also follow safety rules when working with poisons and hazardous chemicals. If you suspect poisoning, you should immediately seek medical help.