Pilocarpine

Pilocarpine: a cholinomimetic agent with selective neurotoxic effects

Pilocarpine is a cholinomimetic drug that is widely used in medicine to treat various diseases and conditions. It has a selective neurotoxic effect on the human body and can cause a number of side effects.

Pilocarpine is used in medicine for the treatment of glaucoma, xerostomia (dry mouth), as well as for the diagnosis of myasthenia gravis and other diseases associated with deterioration of muscle tone. It can also be used to stimulate sweating in the treatment of hyperhidrosis.

However, despite its benefits, pilocarpine may cause unwanted side effects due to its selective neurotoxic effects. These effects may include facial flushing, asthmatic condition, bronchorrhea, drooling, profuse sweating, vomiting, diarrhea, constricted pupils, irregular pulse, cyanosis and collapse. The toxic dose of pilocarpine is over 0.02 grams.

In case of an overdose of pilocarpine, you should immediately seek medical help. Treatment should include gastric lavage with a 0.1% solution of potassium permanganate, followed by the administration of a saline laxative and activated charcoal. Forced diuresis is also recommended. To eliminate bronchorrhea, it is recommended to use atropine, administered subcutaneously or intravenously at a dose of 2-3 ml of a 0.1% solution until bronchorrhea is eliminated.

In conclusion, pilocarpine is a cholinomimetic drug with selective neurotoxic effects that may be useful in the treatment of some diseases, but can also cause serious side effects. In case of an overdose of pilocarpine, you should immediately seek medical help.

Pilocarpine tablets, drops and films for the eyes are drugs that have cholinomimetic properties. This means that they stimulate the production of secretion in the lacrimal gland (M-cholinergic receptors), which improves the outflow of tear fluid, prevents swelling and improves vision. These products have a wide range of applications and can help solve various vision problems such as blurred vision, fatigue