Psychosis Brucellosis

Brucellosis psychosis (lat. Psychosis brucelloza) is a mental disorder observed in people who have had brucellosis - it is an infectious zooanthroponotic disease that occurs with a varied clinical picture, often acquiring a protracted course with periodic exacerbations and accompanied by prolonged joint and muscle pain syndrome, asthenovegetative phenomena, decreased ability to work. Psychoses are possible both in the prodromal period (usually acute) and during the period of subsidence of the disease. The main symptom is a hallucinatory syndrome with visual, auditory, olfactory hallucinations, various illusions, pareidolia, affective disorders in the form of depression or mania and catatonic mental disorders with negativism, a formal change in the level of consciousness, etc. Symptoms of poisoning sometimes have an identical clinical picture with the symptoms of mental disorders.

Etiology of brucellosis psychosis. The following factors play a role in the etiology of mental disorders. Toxic-allergic mechanisms play a role in the formation of toxic psychosis. Pathogenesis is associated with structural changes in neuronal environments that are topographically localized or appear diffusely. Neurons and subcortical structures of the brain are affected already in the 20th day of life, while the hemispheres are affected from the second week. Damage to the temporal and parietal lobes is almost always observed. Hallucinosis is predominantly auditory, with visual or noise occurring less frequently. They can be: elementary, gross (chronic hallucinations), general or partial (like senestopathies, sensory hallucinations) and integral (hallucinatory landscapes). The disease causes various changes in the human nervous system. More often, not only delusional ideas occur, but also obsessive phenomena, which indicates damage to the limbic system and higher structures. The phenomena of interhemispheric assimilation due to the dominance of one of the hemispheres are exposed. With the development of a psychotic state, a disruption in the synthesis of organic, emotional and cortical processes occurs. The phenomena of the inhibitory process and hypothalamic influences on the limbic system are increasing. Endocrine changes are observed. The number of leukocytes and monocytes in the blood decreases, and the concentration of lymphocytes increases. The concentration of protein in the liquor increases. The content of glucose, lactate, cholesterol decreases, and the content of phosphates increases. Amylase, antiphospholipase, blood and urine glucose are reduced (with the presence of ketones and aglucosuria). As the disease progresses, the concentration of enzymes in the blood decreases. At the same time, products that disrupt its metabolism are synthesized, which are antigenic in nature and affect the central nervous system. The functioning of this system is disrupted first.