Verapamil-Ratiopharm

Country of origin - Germany
Pharm-Group - Calcium channel blockers of the phenylalkylamine group

Manufacturers - Ratiopharm GmbH (Germany)
International name - Verapamil
Synonyms - Atsupamil, Vepamil, Veracard, Veramil, Verapabene, Verapamil, Verapamil (Mival), Verapamil hydrochloride, Verapamil-MIK, Verapamil hydrochloride, Vero-Verapamil, Verogalid ER, Veromil, Danistol, Isoptin, Isoptin SR, Kaveril, Lekoptin, Falicard , Falicard long,

Dosage forms - film-coated tablets 40mg, film-coated tablets 80mg, film-coated tablets 120mg, tablets 40mg, tablets 80mg, tablets 120mg

Composition - Active ingredient - Verapamil.

Indications for use - Paroxysmal supraventricular tachycardia (except WPW syndrome), sinus tachycardia, atrial extrasystole, atrial fibrillation and flutter, angina pectoris (including Prinzmetal, tension, post-infarction), arterial hypertension, hypertensive crisis, idiopathic hypertrophic subaortic stenosis, hypertrophic cardiomyopathy.

Contraindications - Hypersensitivity, severe hypotension, cardiogenic shock, AV block II and III degrees, myocardial infarction (acute or recent and complicated by bradycardia, hypotension, left ventricular failure), chronic heart failure stage III, WPW syndrome and sick sinus syndrome ( if a pacemaker is not implanted), sinoatrial blockade, Morgagni-Adams-Stokes syndrome, digitalis intoxication, severe stenosis of the aortic mouth, pregnancy, breastfeeding. Restrictions on use: AV block of the first degree, chronic heart failure stages I and II, severe bradycardia (less 50 beats/min), mild to moderate hypotension, severe myopathy (Duchenne syndrome), liver or kidney dysfunction, ventricular tachycardia with a wide QRS complex (for intravenous administration).

Side effects - From the cardiovascular system and blood (hematopoiesis, hemostasis): hypotension, bradycardia (sinus), AV block, heart failure. From the nervous system and sensory organs: headache, dizziness, nervousness, lethargy, drowsiness, weakness, fatigue, paresthesia. From the gastrointestinal tract: nausea, dyspeptic symptoms, constipation; rarely - gingival hyperplasia, increased activity of liver transaminases, alkaline phosphatase. Allergic reactions: skin rash, urticaria, itching; rarely - angioedema, Stevens-Johnson syndrome. Other: facial skin flushing, bronchospasm (with intravenous administration), peripheral edema, very rarely - gynecomastia, increased prolactin secretion (isolated cases).

Interaction - Increases plasma levels of digoxin, cyclosporine, theophylline, carbamazepine, decreases lithium. Weakens the antibacterial activity of rifampicin, the depressing effect of phenobarbital, the clearance of metoprolol and propranolol, and enhances the effect of muscle relaxants. Rifampicin, sulfinpyrazone, phenobarbital, calcium salts, vitamin D - weaken the effect. The hypotensive effect is enhanced by antihypertensive drugs (diuretics, vasodilators), tricyclic and tetracyclic antidepressants and antipsychotics: antianginal - nitrates. Beta-blockers, class IA antiarrhythmics, cardiac glycosides, inhalational anesthetics, and radiopaque agents potentiate a (mutually) inhibitory effect on the automatism of the sinoatrial node, AV conduction and myocardial contractility. When used simultaneously with acetylsalicylic acid, existing bleeding may increase. Cimetidine increases the plasma levels of verapamil. The injection form is incompatible with albumin, injection