Eroline

**Loratadine produced in Hungary from Egis Pharm.**

**Description**

Loratadine is a selective blocker of peripheral H-1 receptors and an inhibitor of histamine release from mast cells, has antiallergic and antipruritic effects.

Enters the blood within 30 minutes after ingestion, binding to plasma proteins is 97%. Excreted in breast milk. Metabolized during the “first pass” through the liver. Has high ground clearance. It is excreted in the form of metabolites mainly with bile and feces, 31% is excreted unchanged in the urine. It is subjected to intensive metabolism and has a short half-life. Approximately 83-89% of doses are excreted within 3.3-96 hours in feces and slightly in urine (less than 1%). The half-life averages 7.8 hours and is linear; food intake, alcohol, and smoking do not affect the pharmacokinetic parameters. The pharmacokinetics of loratadine is linear. Average Vd is about 17.4 l/kg. With long-term use accumulates mainly in mice