Andriol

Manufacturer country

Netherlands

Pharm Group

Male sex hormones (androgens) and their analogues

Manufacturers

Organon N.V. (Netherlands)

International name

Testosterone

Synonyms

Androgel, Nebido, Nuvir, Testosterone propionate

Dosage forms

capsules 40mg

Compound

The active substance is testosterone.

Indications for use

Androgen deficiency in men: delayed puberty, oligospermia, post-castration syndrome, underdevelopment of the genital organs, hypopituitrism, infertility due to impaired spermatogenesis, menopausal syndrome, impotence, osteoporosis. In women: hyperestrogenism, uterine fibroids, endometriosis, menopause (in combination with estrogens), premenstrual tension syndrome, breast cancer, osteoporosis. Androgel: Replacement therapy for testosterone deficiency.

Contraindications

Hypersensitivity, established or suspected carcinoma of the prostate and/or mammary glands, nephrosis or nephrotic phase of nephritis, hypercalcemia, edema, impaired liver and kidney function, diabetes mellitus, prostatic hypertrophy with symptoms of urinary disorders, heart and coronary failure, history of myocardial infarction, atherosclerosis in elderly men, pregnancy, breastfeeding. Androgel: There is no experience with the use of Androgel in women and children. Carefully. Malignant neoplasms (due to the danger of hypercalcemia and hypercalciuria); severe heart, liver or kidney failure; cardiac ischemia; arterial hypertension; epilepsy; migraine.

Side effect

Premature puberty, prostate anomalies and cancer, increased sexual arousal and increased frequency of erections, penile enlargement, priapism, oligospermia, decreased ejaculate volume, sodium and water retention, premature closure of bone growth zones; headache, depression, anxiety, sleep disturbance, paresthesia, bleeding in the gastrointestinal tract, nausea, cholestatic jaundice, other androgenic effects (hirsutism, seborrhea, acne, etc.). Androgel: The most common adverse effects when using the recommended dose of 5 g of gel per day were skin reactions: erythema, acne, dry skin. In isolated cases, the following were noted: changes in laboratory test results (polycythemia, decreased lipid levels), headache; gynecomastia, mastodynia. From the central and peripheral nervous system - dizziness, paresthesia, hyperesthesia, mood changes; from the cardiovascular system - increased blood pressure; from the gastrointestinal tract - diarrhea; on the part of the skin and its appendages - alopecia. When high dosages are prescribed, irritability, nervousness, weight gain, and prolonged or frequent erections may develop.

Interaction

Increases the effect of indirect anticoagulants (warfarin, nicumalon, phenylin) and hypoglycemic agents, inhibits the excretion of cyclosporine. Barbiturates and alcohol reduce the effect. Androgel: In patients with diabetes, the metabolic effect of using Androgel may lead to a decrease in blood glucose levels and, therefore, require a reduction in the insulin dose. It is recommended to monitor prothrombin time. Coadministration of testosterone and ACTH or corticosteroids may increase the risk of edema. Effect on Laboratory Tests: Androgens may decrease thyroxine-binding globulin levels, resulting in decreased serum T4 concentrations and increased sensitivity to T3 and T4.

Overdose

No data.

special instructions

If androgen-dependent adverse reactions occur, treatment is stopped until they disappear and resumed with reduced doses. Androgel: Used only for testosterone deficiency, accompanied by regression of secondary sexual characteristics, changes in body structure, asthenia, sleep