Donnell's Symptom

Donnelly's sign, or Donnany's syndrome, is a rare condition that causes swelling of the legs due to dilation of the capillaries. This disease is also called Banson's disease. The disease can lead to disability and become a threat to the patient's life. The disease is characterized by inflammatory processes in the veins, increased capillary permeability and accumulation of plasma in the intercellular space, that is, edema develops. In severe cases, its parts begin to stick together, which leads to phlebosclerosis, damage to the eyeballs and joints. Rarely, cases of liver dysfunction occur, which can be confused with steatosis and other diseases.

The syndrome comes from the name of the American surgeon Willis Donnelly, who discovered the presence of venous coagulation blood clots that provoked the syndrome. The syndrome is also called Ishi's disease, Holden's disease, benign lymphoreticulosarcomatosis, Donan's disease, and Kawasaki disease. This is how neurosurgeon Dmitry Bormashov describes it: “The syndrome has been known to doctors for quite a long time. The mechanism of development of postthrombophlebitis syndrome is directly related to its appearance. But it was difficult to identify the disease because it has no specific symptoms.” Basically, doctors examined the disease using histological tissue analysis and scanned the skin for the presence of angiectasia. And since the symptoms are similar to other diseases, it is impossible to distinguish Donnelly syndrome without specific diagnostic measures, eye x-rays, and blood tests for antibodies.