Hemosiderosis of the Skin Reticular Progressive

Hemosiderosis cutanea reticulata (HSCR) is a chronic skin disease that occurs due to excess iron in the body. During illness, the blood vessels in the skin become thin and fragile, and blood leaks into the skin and forms red spots on the skin. These spots can increase in size and appear on any part of the body.

HSCR can cause frequent joint pain, fever, dizziness and general weakness. Treatment depends on the severity of the disease. People with HSCR may receive medications to reduce the amount of iron in the blood, or even blood transfusions.

As for the symptoms of HSCR, it may be

Hemosiderosis is an allergic skin disease caused by a disorder of the immune system. It occurs if an increased amount of iron begins to accumulate in the blood, this affects the development of connective tissue, which normally should produce intercellular substance. In other words, too many cells are formed that actively begin to fill with iron, resulting in characteristic reddish spots with a purple tint. **From hemorrhagic diathesis to Minkowski-Schaffar disease** It is known that red blood cells - erythrocytes - contain hemoglobin. This is an iron-containing protein that provides them with the ability to carry oxygen throughout the body from the lungs to the tissues and deliver carbon dioxide to the cells. In addition to performing its main function, hemoglobin, like any other blood element, can accumulate in the body. Excess iron can not only saturate with oxygen, but also combine with the cytochrome protein in mitochondria, the organelles responsible for cellular respiration. As a result of their work, iron is released. Normally, the protein metallothionein is synthesized to bind excess iron. Unfortunately, for one reason or another, it cannot cope with its duties, and therefore iron penetrates the cells of the skin and internal organs. Cell proliferation leads to the deposition of hemosiderin pigment in places where iron accumulates. This explains the usual color of red blood cells - the skin owes its red tint to the pigment hemosiderin. In fact, this mechanism is the mechanism for triggering the process of activation of cells present in tissues that do not have their own “reproduction”. Among them are lymphocytes, which are carriers of immunity. The activation process is always accompanied by hyperplasia - the formation of new elements under the influence of excess stimulation, or an increase in the activity of existing ones. Lymphocytes do a significant job of cleansing the body, neutralizing various agents (toxic substances, chemical irritants