Hyperbilirubinemia Physiological

Physiological hyperbilirubinemia or physiological indirect bilirubin is defined as the normal level of indirect bilirubin in infants less than 28 days old; it does not require treatment as the bilirubin level decreases on its own. Normal levels of indirect billinrubin are not considered life-threatening in children of this age, given their large livers and spleens.

Bilirubin is a byproduct of the breakdown of red blood cells - Hemoglobin. It is found in the blood of humans and animals. Bilirubin makes up 20–50% of the total blood volume.

The main component of blood is hemoglobin, which contains iron and vitamin B9. When this substance breaks down, bilirubin (or bile) is formed. Only 3% of all hemoglobin enters the circulatory system. The remaining cells are destroyed faster, and this process of bile formation occurs differently - the protein part breaks down into ketone, urobilin and stercobilin, which mostly exit through the intestines. But a small percentage of these substances must be obtained through the blood. This is exactly the task that bilirubin performs.

The production of bile pigment is due to the active work of a number of enzymes that are found only in the liver and cells

Physiological hyperbilirubinemia refers to situations when a patient has a significant excess of normal bilirubin levels in the body. Increased bilirubin can be a consequence of various circumstances, and its amount determines the clinical picture of the disease. Bilirubin is formed as a result of the breakdown of hemoglobin in the cells of the liver and spleen, and with the breakdown of one gram of hemoglobin