Histiocytosis

Histiocytes are multinucleated phagocytes that synthesize large amounts of myeloperoxidase. They belong to the auxiliary cells of connective tissue and participate in the processes of reparative regeneration of damaged tissues, as well as in the destruction of old and damaged cells. In accordance with the process of plastic degeneration of plasma cells, during their degeneration, large histiocytes are formed due to adhesion. These cells have cytoplasmic granular inclusions containing β-globulin residues - the enzyme myeloperoxidase. Myeloperoxidase is an enzyme that plays a key role in the formation of a positive reaction to hematoidin and hematin, and therefore is the main means of diagnosing histiocytes.

Classification: - eosinophilic granuloma (Langerhans cell histiocytosis) - characterized by focal infiltration of the skin with eosinophilic cells activated by Langerhans histiocytes, involvement of joints in the pathological process (up to the development of localized giant cell arthropathy), damage to the lungs and soft tissues. In this case, uveitis often develops, accompanied by proptosis.