Glomerulonephritis Membranous

Membranous glomerulonephritis: Description and main characteristics

Membranous glomerulonephritis, also known as diffuse membranous glomerulopathy or perimembranous glomerulonephritis, is a form of chronic glomerulonephritis. This condition affects the glomeruli, the filtration units of the kidneys that are responsible for filtering the blood and removing waste from the body.

Membranous glomerulonephritis is characterized by inflammation and thick deposition of immune complexes in the vascular wall of the glomeruli. This leads to damage to the glomerular membrane and disruption of their normal function. The key feature of this disease is diffuse membrane damage, unlike other forms of glomerulonephritis, which may affect only certain areas of the glomeruli.

The reasons for the development of membranous glomerulonephritis are not yet fully understood. However, it is believed that autoimmune processes may play a key role in its development. Immune complexes containing antibodies and antigens settle in the glomerular membrane and cause inflammation. This leads to damage to the membrane and loss of its normal function.

Membranous glomerulonephritis often progresses more slowly, so symptoms may be subtle or mild in the initial stages. However, as the disease progresses, the following symptoms may occur:

1. Protein in urine: This is one of the most common signs of membranous glomerulonephritis. The protein, which usually does not penetrate the kidney filters, begins to be excreted in the urine due to damage to the glomerular membrane.

2. Swelling: Due to the kidneys' reduced ability to retain fluid, swelling may occur in the legs, lower extremities, and sometimes other parts of the body.

3. High blood pressure: Damage to the glomeruli can lead to high blood pressure, which requires monitoring and treatment.

4. Deterioration of kidney function: As the disease progresses, kidney function may deteriorate, which can lead to the development of chronic kidney failure.

To diagnose membranous glomerulonephritis, various tests are performed, including urine and blood tests, renal biopsy and instrumental examination methods. These methods will help doctors determine the nature of glomerular damage and assess the extent of kidney damage.

Treatment of membranous glomerulonephritis depends on the degree of kidney damage and the presence of symptoms. In some cases, especially with mild disease, conservative therapy aimed at controlling blood pressure and protein levels in the urine may be sufficient. More severe cases may require the use of immunosuppressants or corticosteroids to reduce inflammation and protect the kidney tissue.

In some cases, when membranous glomerulonephritis leads to the development of chronic renal failure and acute or life-threatening complications, renal replacement such as hemodialysis or kidney transplantation may be required.

In general, the prognosis of membranous glomerulonephritis depends on many factors, including the degree of kidney damage, the effectiveness of treatment and the timeliness of its initiation. Seeing your doctor early if you suspect you have kidney disease and following treatment and symptom management guidelines can help slow the progression of the disease and preserve kidney function.

In conclusion, glomerulonephritis membranous is a form of chronic glomerulonephritis characterized by damage to the membrane of the renal glomeruli. This disease requires diagnosis and treatment by qualified specialists. Seeing your doctor promptly, following recommendations, and monitoring symptoms can help manage the disease and maintain kidney health.

Glomerulonephritis membranous Glomerulonephritis (GN) is a group of syndromes that are characterized by systemic damage to the glomeruli of the kidneys, which leads to disruption of their function. The specific mechanisms and links of glomerular damage in different forms of GN are different and are currently being studied. Despite its existence for many decades, the exact concept of the disease is only available in the hypertensive form. What is the definition of the membrane form of GN? Membrane glomerulonephritis is a lesion of the structure of the basement membrane of the glomerular capillaries, expressed by biochemical changes caused by dysfunction of the capillaries of the glomerular system, which is accompanied by proteinuria, an atypical decrease in glomerular function and symptoms of acute or chronic renal failure. The disease is characterized by particularly severe kidney damage and a tendency to become chronic; it often requires hemodialysis through an artificially created filter. This form is most common in children and adolescents. Adults rarely suffer from this type of pathology. The symptoms, clinical picture, and course of the disease are similar to other forms of GN. Despite a certain similarity of the pathological process, the membrane form of GN is a rare pathology, occurring in 5% of cases of all forms of the disease. The lack of information about the form of the disease makes its diagnosis even more difficult. Treatment tactics and drug support are also different for each type of disease. Since the disease has its own ICD code, it is subject to mandatory registration in the patient’s medical record. How does this form of the disease differ from the others? Physicians should examine the overall clinical picture and possible concomitant diseases to determine whether symptoms are associated with the disease with the possible development of renal failure, hypovolemia. Also, the presence of blood impurities in the urine allows us to establish increased permeability of the vessels of the urinary system and other organs. The following laboratory tests are carried out:

general blood; 24-hour blood urine creatinine;