Glucocorticoids

Introduction: Glycocorticoid drugs are one of the main groups of drugs used in medicine to treat various diseases. They are adrenal hormones and have powerful anti-inflammatory and immunosuppressive effects. It should be noted that they can also cause a number of side effects and complications that require special attention when using them. In this article we will consider the main aspects associated with the use of glycocorticoids in medical practice.

1. Mechanism of action: The action of glycocorticoid drugs is based on the ability to regulate the synthesis of substances associated with inflammation and the body’s immune response. Glycocorticosteroids cause a number of changes in cells and tissues, inhibiting the production of cytokines (for example, interleukin-1), which promote inflammation and the development of immune reactions. In addition, glycocorticosteroids reduce the formation of substances that promote the development of malignant tumors. The effect of glycocorticosteroid drugs is also realized through their influence on vascular tone and blood pressure regulation. 2. Indications for use: - allergic reactions, bronchial asthma, atopic dermatitis, eczema, rheumatoid arthritis, allergic rhinitis, autoimmune diseases; - severe infections (drugs for pulse therapy for influenza, hepatitis, and tuberculosis); - and also to reduce the likelihood of transplanted organ rejection. 3. Side effects and complications: The following side effects are most often observed when using glucocorticoids: - increased muscle tone, the appearance of edema due to an increase in blood glucose levels (glucocorticoids cause hyperglycemia); - exacerbation of gastric and duodenal ulcers (if you simultaneously use one drug from the group and other drugs to reduce acidity or drugs that promote the formation of gastric juice); - cardiodepression (heart rhythm disturbances, low blood pressure, cardiac arrhythmia); 4. Intermediates between types of glucocorticoid hormone: Similar affinity for glucocorticoids, like pgn-I, produces glucocorticoid receptors, activating intracellular protein kinases. It is assumed that gk RNA may play the role of a primary messenger involved in signal transmission from glucocorticoid receptors to nuclear factors. Others suggest that the change