Glucose-6-Phosphate Dehydrogenase Deficiency

Glucose-6-Phosphate-Dehydrogenase deficiency (G6PD) is a genetic disorder that is inherited through recessive inheritance. In people suffering from this disease, the enzyme glucose-6phosphate dehydrogenase, which is involved in carbohydrate metabolism in the body's cells, is absent or does not function properly. This leads to disruption of the process of glucose oxidation and destruction of red blood cells, which in turn can lead to anemia and other serious consequences.

Symptoms of G6PD deficiency begin in childhood and may include an enlarged liver, jaundice, pallor, weakness, increased sensitivity to infections, anemia, and low blood sugar. Some people with G6PD deficiency may have increased sensitivity to certain medications, infections, and other stressors, which can lead to hemolytic crises.

Treatment for G6PD deficiency involves avoiding factors that can trigger hemolytic crises, such as medications, infections, stress, and certain foods. Patients with G6PD deficiency are advised to avoid foods containing galactose and fructose and to take glucose frequently to maintain blood sugar levels. In some cases, blood transfusion or other treatments may be required.

G6PD deficiency can be compared to another genetic disorder called favism. Favism is also an inherited disease that leads to the destruction of red blood cells and anemia when certain types of beans are consumed. As with G6PD deficiency, patients with favism are advised to avoid foods that cause hemolytic crises and to take frequent glucose and other measures to maintain health.

In conclusion, Glucose-6-Phosphate-Dehydrogenase Deficiency (G6PD) is a serious genetic disorder that can lead to various complications if left untreated. Treatment of this disease consists of avoiding factors that can cause hemolytic crises, as well as taking measures to maintain health. If you suspect you have G6PD deficiency, see your doctor for diagnosis and treatment. It is important to remember that proper treatment and care allows people with G6PD deficiency to live full lives despite this genetic abnormality.

Glucose-6phosphate dehydrogenase deficiency (G6PDH) is a hereditary disease that is characterized by the absence or insufficient activity of the enzyme glucose-6phosphate dehydrogenase in the human body. This enzyme plays an important role in carbohydrate metabolism, enabling the production of several important molecules and protecting red blood cells from oxidative damage.

G6PD is the most common enzyme deficiency affecting red blood cells (RBCs). It is inherited in a predominantly recessive manner, meaning that for the disease to occur, you must inherit the wrong gene from both parents.

Symptoms and manifestations of G6PD can vary from person to person, but it usually appears during childhood. One of the most characteristic symptoms is hemolytic anemia, which develops as a result of accelerated destruction of red blood cells. Patients may experience weakness, paleness, fatigue, jaundice, and dark-colored urine.

In addition to hemolytic anemia, G6PD can also cause other complications. Taking certain medications, infections, or eating certain foods, such as beans and antioxidants, can trigger a hemolytic attack. This condition is characterized by rapid destruction of red blood cells, resulting in severe pallor, jaundice, fatigue, and in some cases may be complicated by acute renal failure.

The diagnosis of G6PD is usually made through laboratory tests, including measuring the activity of the G6PD enzyme or genetic testing to look for mutations in the genes responsible for producing the enzyme.

Treatment of G6PD involves monitoring certain medications and avoiding factors that can cause hemolytic attacks. If complications occur that require medical intervention, hospitalization and specialized treatment may be required.

It is important to note that G6PDH should not be confused with another genetic disorder known as favism. Favism is also a form of hemolytic anemia, but is caused by intolerance to certain foods such as fava beans. Unlike G6PD, favism is not associated with a deficiency of the G6PD enzyme and has other developmental mechanisms.

In conclusion, Glucose-6Phosphate Dehydrogenase (G6PDH) deficiency is an inherited disorder characterized by insufficient activity of the enzyme glucose-6phosphate dehydrogenase. This can cause hemolytic anemia and other complications. Diagnosis is made through laboratory tests, and treatment includes monitoring medications and avoiding triggers that can cause hemolytic attacks. Patients are encouraged to consult regularly with their physician and follow recommendations for managing their condition to maintain optimal health and prevent complications.

Glucose-6 phosphate dehydrogenase deficiency is an inherited disease that causes an enlarged liver and decreased sugar levels in the bloodstream. This enzyme is involved in the process of carbohydrate metabolism, with a lack of which the level of glucose in the body decreases. Treatment for this disease involves taking large doses of glucose and avoiding foods containing galactose or fructose, which can worsen symptoms.

The most surprising thing is that hereditary deficiency of glucose-6 phosphate dehydrogenase activity is one of the most common types of childhood diabetes. Moreover, of all the children with a congenital glucose defect and a decrease in its use and drinking, as is emphasized throughout the world, it is those unborn without this weakness that suffer much less often from infant death from bad luck. The incidence of this type of deficiency is about 1% for unmarried women of the total number of births worldwide. Or for mothers who haven't had a healthy pregnancy until age 20 or 35. Cause endocrine changes characteristic difficulties in each child have up to half of them.

Also, 7-8% of children suffering from a classic reaction to liver injury develop G-6-FDG deficiency. These cases