Heparoid

Country of origin: Czech Republic
Pharm-Group: Direct acting anticoagulants

Manufacturers: Spofa Prague (Czech Republic)
International name: Heparin sodium
Synonyms: Heparibene sodium, Heparin, Heparin "Biochemi", Heparin Biochemi, Heparin BS, Heparin Lechiva, Heparin-sodium Brown, Heparin-Richter, Heparin-Ferein, Heparin-Ferein, Heparin sodium salt, Heparoid Lechiva, Lyoton 1000, Sodium heparin , Trombless, Trombofo
Dosage forms: ointment
Composition: Active substance - sodium heparin.

Indications for use: Unstable angina, acute myocardial infarction; thromboembolic complications during myocardial infarction, operations on the heart and blood vessels, thromboembolism of pulmonary and cerebral vessels, thrombophlebitis; DIC syndrome, prevention of microthrombosis and microcirculation disorders; renal vein thrombosis; hemolytic-uremic syndrome; atrial fibrillation, mitral heart defects; bacterial endocarditis; glomerulonephritis; lupus nephritis; rheumatism; bronchial asthma; carrying out extracorporeal methods (extracorporeal circulation during cardiac surgery, hemosorption, hemodialysis, peritoneal dialysis, cytapheresis), forced diuresis; flushing venous catheters.

Contraindications: Hypersensitivity, hemorrhagic diathesis, leukemia, anemia, increased vascular permeability, polyps, malignant neoplasms and ulcerative lesions of the gastrointestinal tract, severe dysfunction of the liver and kidneys, surgery on the brain and spine.

Side effects: Dizziness, headaches, nausea, anorexia, vomiting, diarrhea, alopecia; early (2-4 days of treatment) and late (autoimmune) thrombocytopenia; hemorrhagic complications - bleeding in the gastrointestinal tract or urinary tract, retroperitoneal hemorrhages in the ovaries, adrenal glands (with the development of acute adrenal insufficiency), osteoporosis, soft tissue calcification, inhibition of aldosterone synthesis, increased levels of transaminases in the blood, allergic reactions (fever, rashes, bronchial asthma, anaphylactoid reaction), local irritation, hematoma, pain upon injection.

Interaction: The effectiveness is enhanced by acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, warfarin, dicoumarin, and weakened by cardiac glycosides, tetracyclines, antihistamines, nicotinic acid, ethacrynic acid.

Overdose: Symptoms: bleeding of varying severity. Treatment: in case of minor bleeding, reduce the dose or stop using the drug; in case of severe bleeding, a 1% solution of protamine sulfate is slowly administered intravenously.

Special instructions: Use during pregnancy and breastfeeding is possible only under strict indications. Constant monitoring of blood clotting time is necessary; withdrawal should be carried out gradually.

Literature: Encyclopedia of Medicines 2002, issue 9.