Cholangiocarcinoma

Cholangiocanroa is a malignant neoplasm that originates from the walls of the bile duct of the liver. The pathology may arise as a metastasis from another malignant neoplasm, such as cancer. The cause of the tumor may also be cirrhosis of the liver, non-alcoholic steatohepatitis, inflammatory damage to hepatocytes or other pathologies.

Cholangiocan develops from the glandular cells of one of the sections of the bile ducts (choledochus). Namely, from those cells that control the formation and outflow of bile. With the blood flow, the cells receive signals from the affected liver cells and begin to grow uncontrollably in the bile duct. As a result, the function of the duct is disrupted, which leads to clinical manifestations of the disease. Symptoms of cholangiocancer (formerly cholangioadenocarcinoma) usually depend on the degree of the oncological process, as well as on the location of the tumor. That is, tumors can be both large and small, which are difficult to diagnose without medical instruments. Most often, the symptoms of cholangiocrema begin to appear in the later stages, so patients miss the onset of the disease. When the tumor is located in large ducts, the risk of developing yellowness of the skin and mucous membranes increases; in women, ascites (enlargement of the abdominal cavity) and severe edema may appear. If the cancer affects the fibrous lining of the gallbladder, the patient will experience severe pain in the right side of the abdomen. But since the tumor is located inside the organ, the pain is not intense enough. If it attaches to neighboring organs of the abdominal cavity, then the pain intensifies and becomes almost unbearable. Other signs of cholangiocarcinoma include elevated temperature, general loss of strength, and enlarged liver. If cancer cells penetrate the lymphatic vessels, subcutaneous lymph nodes will appear on the patient's skin. Changes in the intestinal mucosa, vomiting with blood, gas, black or brown urine are signs of life-threatening conditions in which surgical intervention may no longer help to cope with the pathology.

It is known that predisposing factors for cholanginardenocarcinoma include obesity, diabetes, alcoholism, long-term use of medications (for example, hormonal drugs), and smoking. Treatment In the initial stages, the disease can be cured, but only if the large ducts have not been damaged. Surgery is necessary because the affected cells begin to wash out through them. The most difficult case is the removal of tumors that form in the intrahepatic bile ducts. This is due to the thickness

Cholangiocanromarcinoma is a malignancy that arises in the bile tree (also known as the bile ducts), which is part of the digestive system. It is one of the most dangerous types of cancer that can occur in the human body. The cause of cholangiocanramarcinoma is not yet fully understood, but various risk factors have been identified, such as exposure to toxic substances, smoking, alcohol consumption and genetic predispositions.

The tumor can begin to grow anywhere in the bile ducts, although the most common location is the junction of the right and left branches of the bile duct. In most cases, it manifests itself with symptoms such as pain in the right hypochondrium, jaundice and dark urine. These symptoms can lead to the development of chronic liver disease and even cirrhosis of the liver.

Treatment of cholangiocaromorcinoma depends on the stage of the disease, tumor size and the presence of other concomitant diseases. Surgical resection of the biliary tract is the first-line treatment, but chemotherapy, radiation therapy, and other treatments may also be used. Unfortunately, relapses of cholangiocarmomarcinomas have become more common recently, and many patients still face problems after treatment. In such cases, patients with cholangiomarcinoma are advised to undergo regular examinations and monitor their overall condition.