Hyaluronidase

Hyaluronidase (syn. hyaluronate glycanohydrolase) is an enzyme that catalyzes the breakdown of hyaluronic acid. Hyaluronic acid is the main component of the extracellular matrix of connective tissue.

Hyaluronidase destroys hyaluronic acid, which leads to a decrease in the viscosity of connective tissue. This facilitates the diffusion of substances through connective tissue.

Hyaluronidase is produced by some microorganisms and is also present in humans and animals. It plays an important role in fertilization, inflammation, and tumor metastasis.

Hyaluronidase is used in medicine to improve the penetration of drugs when administered subcutaneously. It is also used in cosmetology to correct wrinkles.

Hyaluronase is an enzyme that destroys hyaluronic acid compounds and thus affects cell membrane permeability, immunity, inflammation and tissue regeneration. It is involved in regulating many processes in the body, especially wound healing, increasing articular cartilage and joint maintenance, improving vision, reducing wrinkles, skin production and urinary tract functions.

History of the discovery of hyaluronidase Hyaluronidase was first isolated from mouse testicular tissue by P.D. Perkins and S.T.