Country of origin - Poland, ICN Polfa Rzeszow Poland, Warsaw Pharmaceutical Plant Polfa Poland, Krakow Pharmaceutical Plant Polfa Poland, Poznan Pharmaceutical Plant SA Polfa Poland, Polfa Poland
Pharm-Group - Anti-inflammatory drugs - indoleacetic acid derivatives
Manufacturers - Polfa, Rzeszowskie Zaklady Farmaceutyczne SA (Poland), ICN Polfa Rzeszow (Poland), Warsaw Pharmaceutical Plant Polfa (Poland), Krakow Pharmaceutical Plant Polfa (Poland), Poznan Pharmaceutical Plant SA Polfa (Poland), Polfa (Poland)
International name - Indomethacin
Synonyms - Apo-Indomethacin, Vero-Indomitacin, Indobene, Indovis E.S., Indocollir, Indomet-Ratiopharm, Indomethacin, Indomethacin (Movimed), Indomethacin 100 Berlin-Chemie, Indomethacin 50 Berlin-Chemie, Indomethacin Vramed, Indomethacin Sevtopolis, Indomethacin Sopharma, Indomet
Dosage forms - ointment, injection solution 3%, film-coated tablets 25 mg, retard tablets 75 mg, dragees 25 mg, ointment 5%, suppositories 100 mg, suppositories 50 mg, injection solution 60 mg
Composition - Active substance: Indomethacin.
Indications for use: Rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, tendonitis, synovitis, acute gouty arthritis, reactive arthritis.
Contraindications - Hypersensitivity, rhinitis, conjunctivitis or bronchospasm while taking NSAIDs, erosive and ulcerative lesions of the gastrointestinal tract, bleeding (especially intracranial or from the gastrointestinal tract), thrombocytopenia, hypocoagulation, suspicion of necrotizing enterocolitis, severe renal failure, congenital heart defects (tetralogy of Fallot, atresia pulmonary artery), proctitis (suppositories), pregnancy (teratogenicity may occur).
Side effects - Nausea, vomiting, epigastric pain, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, rectal bleeding, toxic hepatitis, constipation, arterial hypertension, heart rhythm disturbances, bone marrow hypoplasia, aplastic anemia, autoimmune hemolytic anemia, agranulocytosis, thrombocytopenia, platelet dysfunction, fluid retention, hyperglycemia, glycosuria, hyperkalemia, pruritus, urticaria, exfoliative dermatitis, hair loss, erythema nodosum, Stevens-Johnson syndrome, anaphylactic shock, bronchospasm, vasculitis, pulmonary edema.
Interaction - Reduces the diuretic effect of potassium-sparing, thiazide and loop diuretics, hypotension caused by beta-blockers. Increases (mutually) the risk of developing side effects (primarily gastrointestinal lesions) of other NSAIDs. Increases the toxicity of methotrexate (reduces its tubular secretion). Causes an increase in the levels of lithium and digoxin in plasma.
Overdose - Symptoms: Nausea, vomiting, severe headache, dizziness, memory impairment, disorientation. In more severe cases, paresthesia, numbness of the limbs and convulsions are observed. Treatment: Symptomatic. Indomethacin cannot be removed from the body by hemodialysis.
Special instructions - Particularly careful medical supervision is required for: gastrointestinal diseases, chronic heart failure, arterial hypertension, bleeding disorders, liver dysfunction, old age, immediately after surgery, mental disorders, depression, parkinsonism, epilepsy, bronchial asthma, allergic rhinitis , nasal polyps, chronic respiratory diseases and chronic respiratory tract infections. Indomethacin should be prescribed with caution to people engaged in potentially hazardous activities that require increased concentration and mental alertness.