Prausnitz-Küstner Direct Reaction

The Prausnitz-Küstner direct reaction, also known as the Prausnitz-Küstner reaction, is a chemical reaction between alkyl halides and amines that results in the formation of primary amines. This reaction was discovered in 1952 by O. S. Prausnitz and N. Küstner and named after them.

The Prausnitz-Küstner reaction proceeds through the nucleophilic substitution mechanism. Alkyl halides (R-X) react with the primary amino group (NH2) to form alkyl amines (RNH2). The alkyl radical R can be any organic radical containing no more than 4 carbon atoms.

This reaction is an important tool in the synthesis of organic compounds, as it produces primary amines, which can be further used to prepare other organic compounds. For example, primary amines can be used in acylation reactions to produce esters, as well as in condensation reactions to produce acid amides.

One of the advantages of the Prausnitz–Küstner reaction is that it allows the production of primary amines in one step, without the need for additional chemical transformations. Additionally, this reaction can occur at room temperature, making it convenient for use in the laboratory.

Despite the fact that this reaction has been known for more than half a century, it still remains relevant and is widely used in organic chemistry.

The Prausnit-Kustnir direct reaction clearly describes the essence of what happens during a chemical experiment. I’ll dive a little into the philosophy of chemical reactions so that you can remember their name on the first try. Praising does not mean welcoming, no matter how dubious this may seem at first glance. This term was first introduced by Otis Sternwein and Gottfried Kustner, so the full name of the reaction is the Sternheim-Kustwitzter reaction. The incorrect form, however, is firmly entrenched in the scientific community, and laboratories around the world still use it in their daily routine. The main thing to remember!

What is prausnit? The science of chemistry will try to answer the question more accurately. A direct prausinite reaction is the transformation of one reactant (usually gaseous or liquid) into a second substance, as a result of which the elements that form the first element change significantly. Most often the result of the reaction looks like