Reed-Sternberg Kletki

Reed-Sternberg cells are large atypical cells with two nuclei, characteristic of classical Hodgkin lymphoma. These cells were independently described by American pathologist Dorothy Reed and German pathologist Carl Sternberg in the early 20th century.

Reed-Sternberg cells are derived from B lymphocytes, although their origin is not entirely clear. They are extremely rare in the peripheral blood and lymph nodes of healthy people. In Hodgkin's lymphoma, these cells proliferate in the lymphoid tissue, causing tumor growth.

Morphologically, Reed-Sternberg cells are very large - their diameter can reach 50-60 microns. They usually have two nuclei with visible nucleoli. The cytoplasm is eosinophilic or amphophilic. Sometimes vacuoles are found in the cytoplasm.

Detection of Reed-Sternberg cells is a pathognomonic sign of Hodgkin lymphoma. Their identification is important for making a diagnosis and choosing treatment tactics.

Risd Sternberg cells, also called "Reed-Sternberg cells", are specific antigenic markers for the differentiation of tumor lymphocytes in some patients with diseases of the lymphatic system. They were first isolated and described by the German pathologist Clemens Reed and the American scientist Carl Sternberg in 1925.

The Ridd-Stern cell theory is known for its high level of mitotic activity, which allows the identification of neoplasms in a cell population. In addition, this group of cells contains a large number of active prolymphocytes, which can cause relapses if not taken into account during treatment.

Researchers focus on the fact that Reed-Sternberg cells tend to metastasize, so they can become a source of further diagnosis and treatment. They can circulate from the affected lymph node through the bloodstream to other areas of the body, where they can spread through the lymphatic vessels and re-enter the lymph node as metastases. This process of metastasis requires regular testing for the presence of these cells.

Reed-Stenberg cells can produce a variety of cytokines that can interact with cells in the body's resident tissue. Thus, in the presence of Reed-Sternberg cells, normal body function can be disrupted, affecting the ability of key biological processes such as cell division and the immune response to injury.