Salmonella Typhi

Salmonella typhi is the bacterium that causes typhoid fever. Typhoid fever is an acute human infectious disease caused by the bacterium Salmonella typhi, with a fecal-oral mechanism of transmission of the infectious agent when hygiene rules are violated by contaminated food or through contact and household contact through damaged skin.[1]

The bacteria enters the body through the gastrointestinal tract through the food or water route. The disease is an epidemic despite the development of antibiotics used to treat it. For most people it is mild, but can be fatal. In the territory of the former USSR, typhoid fever was considered one of the priority infections, mainly due to its social significance: approximately 2% of patients die from this disease.

Typhoid fever is an infection that is dangerous due to many factors. Severe toxic-allergic damage to the liver is observed already in the second week of the disease and is manifested by jaundice or impaired liver function.[2]. However, this is not the only pathological process. Allergies and increased vascular permeability play an important role in the pathogenesis of the disease.