Siofor 850

Country of origin: Germany, Berlin-Chemie AG/Menarini Group Germany

Pharm-Group: Antidiabetic agents - biguanides

Manufacturers: Berlin-Chemie AG (Germany), Berlin-Chemie AG/Menarini Group (Germany)

International name: Metformin

Synonyms: Bagomet, Vero-Metformin, Gliminfor, Gliformin, Glucophage, Glucophage, Dianormet, Diformin retard, Metfogamma 500, Metfogamma 850, Metformin, Metformin-BMS, Siofor 500, Formin Pliva

Dosage forms: film-coated tablets 850 mg

Composition: Active substance - metformin hydrochloride.

Indications for use: Type 2 diabetes mellitus with ineffective correction of hyperglycemia by diet therapy, incl. in combination with sulfonylureas; type 1 diabetes mellitus as an adjunct to insulin therapy.

Contraindications: Hypersensitivity, kidney disease or renal failure, severe liver disorders, cardiac and respiratory failure, acute phase of myocardial infarction, infectious diseases, major surgery and trauma, chronic alcoholism, acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma , conducting research using radioactive isotopes of iodine, pregnancy, breastfeeding. Restrictions on use: Children and elderly (over 65 years old) age.

Side effects: At the beginning of the course of treatment - anorexia, diarrhea, nausea, vomiting, flatulence, abdominal pain (reduced when taken with meals); metallic taste; megaloblastic anemia; lactic acidosis (respiratory disturbances, weakness, drowsiness, hypotension, reflex bradyarrhythmia, abdominal pain, myalgia, hypothermia), hypoglycemia; rashes and dermatitis.

Interaction:

1. Phenothiazines, corticosteroids, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium antagonists, isoniazid, thiazide and other diuretics weaken the effect.

2. Insulin, sulfonylurea derivatives, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers enhance the effect.

3. Furosemide increases the maximum concentration. Nifedipine increases absorption, maximum concentration, and prolongs elimination.

4. Amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene and vancomycin during long-term therapy can increase the maximum concentration by 60%.

5. Incompatible with alcohol.

Overdose: Symptoms: lactic acidosis. Treatment: hemodialysis, symptomatic therapy.

Special instructions:

1. It is necessary to constantly monitor kidney function, glomerular filtration, and blood glucose levels.

2. Vitamin B12 levels should be determined once a year.

3. When transferring a patient to metformin, it is prescribed immediately after discontinuation of the previous drug, with the exception of replacing chlorpropamide.

4. It should not be used before surgical operations and within 2 days after them, as well as within 2 days before and after diagnostic studies.

5. Should not be prescribed to people performing heavy physical work.

Literature: Encyclopedia of Medicines 2006.