Thromboagglutination [Throm-Boagglutinatio; Thrombo(Cit) + Agglutinacy]

Platelet aggregates (thromboagglutinins) can form in the blood of humans and animals under normal conditions and pathology. They are conglomerates of many platelets that stick together due to the formation of intercellular bridges. As a result of this process, blood vessels become blocked with blood clots, which is the body’s protective reaction to various damages and injuries. However, in some diseases, for example, in autoimmune processes, thromboagglutinins can be excessive and lead to the development of thrombosis.

The formation of platelet aggregates occurs due to the interaction of platelets with other blood cells, such as red blood cells, white blood cells and other platelets. This interaction occurs through specific receptors on the surface of platelets. In this case, the coagulation cascade is activated, which leads to the formation of fibrin and the formation of a blood clot.

Thromboagglutination can be caused by various factors, including changes in blood composition, the presence of antibodies to platelets, as well as various diseases, such as infectious processes, hemoblastosis, trauma, etc.

Various methods are used to diagnose thromboagglutination, including a blood test for platelet levels, a coagulogram and other studies. Treatment of thromboagglutinations depends on the cause of their occurrence and may include the use of medications, lifestyle changes, etc.

A thromboagulation reaction (or thromboagglutination) is the process of aggregation (sticking together) of blood platelets with the formation of platelet microclots (thrombi), which occurs when there is a specific antigenic cause or substrate for platelet activation in the human body.

The mechanism of the thromboagglutination reaction is a rather complex and multi-stage process that combines various interactions between various factors. This process includes the following steps:

1. Platelets receive a signal from the vessel wall about the need for aggression. 2. Serum factors cause degradation of placental cells and release of thromboplastic substances. 3. Platelet membrane formation is increased due to the synthesis of a large number of membrane proteins, including large glycoproteins. 4. Platelet aggregation causes these cells to stick together, forming platelet microclots. 5. Complementary pathway: During the thromboagglutination process, activation occurs