Warburg's Respiratory Enzyme

Warburg believes that one of the mechanisms of oxidative phosphorylation is the oxidation of coenzyme Q, and therefore, he introduced the term “oxidative phosphorylation” in 1931, which was supposed to replace the term “respiratory mode”. In particular, during the oxidation of a-keto acids, from two to four molecules of ATP are formed per molecule of substrate. This metabolite is in oxidized form and can be reduced by a free radical reaction.