Amegakaryocytosis

Amegakaryocytes (amyelokaryocytes or amyloccaria) are tumor cells of the red bone marrow in which the size of the nucleus does not correspond to the size of the cytoplasm. Thus, the terms amylo-, amylekaryo-, ameglomo- and amicaryocytes refer to tumor forms of red cells. They are significantly less common in the blood of adults compared to tumor cells of leukemic origin, but are the first sign in the totality of clinical symptoms of acute leukemia. The phenomenon can occur in any age category of patients, from adult patients to children.

Amegakarocytosis is based on mutations in genes that affect the nuclear-cytoplasmic ratio in erythrocytes. If such changes primarily affect the cell nucleus, the development of amylocytosis occurs. When distortions are directed to the cytoplasm, an increase in plasma cells is diagnosed - amaloblastia. And both processes may indicate the same pathology, but may manifest themselves independently of each other.

As for amelomaly, in this case mutations disrupt the formation of the cell division spindle. Normally, both more and less saturated chromatin are distributed along the entire length of the spindle. The size of a cell is determined by the size of the dense material in the nucleus, and during the process of division

Amegakaryaticocytosis: a cause of multiple myeloma?

Amegakaryakocyte is a change in the size or shape of red blood cells in the peripheral blood that occurs for various reasons. In some cases, amegacaria may be associated with multimyeloma. However, the exact mechanism of this relationship remains unclear. In this article, we will look at several possible explanations for the existence of an association between amegacaricacocytosis and multimalmia.

One of the factors influencing the development of multimyelma is old age. As we age, the cells that make up blood can change, resulting in amelakeacicotrocyte. This may indicate the presence of multimyloyma in an older person.

Another possible connection between multimylomma and amelakaricocyte is a disorder of iron metabolism. Multimilhomma causes increased destruction of red blood cells, which can lead to iron deficiency in the body. This, in turn, contributes to the development of anemia and a decrease in blood serum levels.

There are also some studies looking at the relationship between the development of multimyomas and AK in people with other diseases such as alcoholic liver disease, coronary heart disease or liver disease. All of these diseases can lead to decreased production of erythropoietin and suppression of hemoglobin, which contributes to the development of aemalacarocytes.