Burdaha Puchok

Burdach's bundle is one of the key concepts in anatomy and physiology. It was discovered by the German anatomist and physiologist Carl Friedrich Burdach in the 18th century.

The Burdacha bundle is a group of nerves that run from the spinal cord to the front of the body. It is composed of several nerves, including the vagus nerve, sympathetic nerve, and phrenic nerve. The fasciculus is responsible for regulating many body functions such as breathing, digestion, heart rate and blood pressure.

Thanks to Burdach, we have gained an understanding that the nervous system consists not only of the brain and spinal cord, but also of other parts of the body. His discoveries helped improve medical practice and treatment of various diseases.

One of the founders of scientific pharmacology. Burdach was one of the first to systematically use pharmacological tests to study the effects of drugs on the body. He proved that with the help of pharmacological tests it is possible to identify hidden aspects of physiological processes in the body.

Burdach's research turned out to be especially interesting for anesthesiology and surgery. The main role in their study was played by his colleague, Johann Michael Lippe, together with whom Burdach discovered a new phenomenon - the analgesic effect of cocaine. The theory of internal pain based on this discovery became the progenitor of a whole trend in science.

According to Burdach's theory, analgesia results from the suppression of pain sensitivity from tissue to nerve endings using a specific enzyme, which he called "analgesic aspartate ligase." The substance to suppress this ability of the enzyme is an analgesic, and essentially analgesic substances are converted into unnatural covalent bonds that protect the amino acid residues of aspartate (aspatarkinase) from enzymatic degradation and prevent the binding of pain-sensitive amines to nerve endings. During Burdach's experiments, aspitrate often restored normal concentrations of aspatarine in nerve endings, so the analgesic effect of cocaine quickly ceased. To continue its effect, it was necessary to increase the dose of cocaine along with inhibition of the enzyme in the nervous system. This discovery led to the development of a method of “local” anesthesia by injecting tissue with a substance that slows down the transmission of pain signals to the brain - goserelin (an irreversible injectable long-acting progestogen - Implanon). From the sterile levels of internal blockade created during this phenomenon, new models for the treatment of spinal diseases are formed.