Hyperkeratosis Ichthyosiform Generalized

Hyperkeratosis ichthyosiformis generalisata is a rare hereditary skin disease that is characterized by excessive keratinization and flaking of the skin throughout the body.

This disease is caused by mutations in genes encoding keratinocyte proteins. This leads to disruption of the processes of differentiation and keratinization of the skin. Clinically manifested by thickening of the stratum corneum of the skin, peeling, dryness and itching. The lesions are widespread and affect the skin of the entire body, especially the extensor surfaces of the limbs.

The diagnosis is made based on the clinical picture and histological examination of the skin. Treatment includes moisturizing and keratolytic ointments, as well as retinoids. Lifelong skin care is necessary to prevent complications. The prognosis is generally favorable with adequate therapy, but the disease significantly worsens the quality of life of patients.

Hyperkeratosis ichthyosiformis (HI) is a disease characterized by thickening and roughening of the skin. GI can be either hereditary or acquired. With this condition, the skin becomes dry, rough and scaly, and may also be itchy.

HI can occur as a result of various reasons, such as genetic disorders, hormonal changes, lack of vitamins and minerals in the body, as well as various skin diseases.

One of the most common types of HI is ichthyosiform generalized (IG). IH is characterized by severe thickening of the skin, which can lead to deformation of the fingers and nails. In addition, IH may cause cracks in the skin, which can be very painful.

Treatment for IH may include various methods, such as the use of creams and ointments to soften the skin, as well as surgery to remove rough areas of skin. In some cases, it may be necessary to take medications to treat the underlying disease that led to the development of IH.

Hyperkeratosis ichthyosiformis can cause serious health problems, so it is important to see a doctor promptly for diagnosis and treatment.