Myocardial infarction Large focal

Large-focal myocardial infarction is a type of myocardial infarction. An extensive infarction develops when the coronary arteries become stenotic and one or more foci of necrosis (necrobiotic changes) develop in the thickness of the myocardium. Serious disturbances in the blood supply to the heart muscle develop, as well as other damage characteristic of a heart attack. Depending on the condition of the person that provoked an extensive or small-focal heart attack, its course can be acute with severe pain (from simple pain and a feeling of discomfort to angina pectoris - sharp pain in the chest) and impaired blood circulation in the ischemic part of the heart.

Large focal myocardial infarction (CMMI) is an acute violation of coronary circulation with the occurrence of multiple foci of necrosis in the myocardium due to thrombosis (compression) of one or more arteries.

Formed thrombosis and peri-infarction ischemia of the myocardium, as well as stretching of the surrounding vessels contribute to the occurrence of edema and hyperemia in the affected area and around it, better known as ischemic changes in the myocardium (ICI), they are preceded by dystrophic changes in the cell. In areas of acute ICI, fragmentation of cardiomyocyte nuclei and cleavage of myosin filaments and sarcolemmal proteins are detected. This occurs from the moment a blood clot forms and the blood supply to this area of ​​the heart muscle is cut off. Most often, a heart attack is manifested by sudden pain behind the sternum, radiating to the left arm, iliac region, and abdominal area.