Eosinophilic cell is a general term for a group of differentiated cells in the body, including white blood cells and one type of macrophage. Their function is to participate in allergic reactions or protect against them, which makes this group of cells indispensable for our immune system.
Segmentation: Leukocytes can be segmented (lymphocytes) or non-segmented (granulocytes). Segmented leukocytes are divided into those that have a nucleus connected to the cytoplasm and those that have a nucleus not connected to the cytoplasm, such as red blood cells. The nucleus will have a relatively thin, segmented body, and the entire cytoplasm will stain more easily than the nucleus.
Not all leukocytes are granulocytes or not; many leukocytes are erythrocytes. When we talk about eosinophilic granulocytic or granular cells, we mean leukocytes or macrophages that have a high content of granules contained outside the nucleus (or on the nucleus itself). These granules are typically colored with a dye called Hematein, which is a yellow-colored hematin acid. If this dye is not used, the coloring is greatly reduced, but if stained with a blue dye, such as acid fuchsin, the eosinphil granules will take on a red-violet color due to the action of an enzyme in the granules that produces “eosin.” Its name comes from the Latin term "eozeinofilus".
For practical purposes, in the context of immunological reactions, there is little benefit in distinguishing between these two groups of leukocytes or macrophages, so the eosinamic marker is of little importance either for routine practice or for the specialization of hematopoiesis, since it is a feature of several diseases.