Cortiazem

Cortiazem: Calcium channel blocker for the treatment of cardiovascular diseases

Introduction

Cortiazem, whose international name is diltiazem, is a pharmacological drug belonging to the group of calcium channel blockers of the benzodiazepine group. It is widely used to treat various cardiovascular diseases such as angina, hypertension and some heart rhythm disorders. In this article we will look at the main characteristics of the drug Cortiazem, its indications for use, contraindications, side effects and interactions with other drugs.

Country of origin and manufacturers

Cortiazem is produced in Yugoslavia by Hemofarm D.D. It is one of the leading pharmaceutical manufacturers in the region and is known for its high quality and reliability.

Dosage form and composition

Cortiazem is available in the form of retard tablets containing 90 mg of diltiazem as the active ingredient. Retard tablets provide a gradual release of the drug into the body, which allows for a long-term and stable treatment effect.

Indications for use

Cortiazem is used to treat the following conditions:

1. Angina: Cortiazem is effective in reducing the frequency and severity of angina attacks, improving the quality of life of patients with this disease.

2. Hypertension: Cortiazem may be prescribed as monotherapy or in combination with other antihypertensive drugs to control blood pressure. It is especially recommended for patients who have had a myocardial infarction or have concomitant angina.

3. Heart rhythm disturbances: Cortiazem is used to relieve paroxysmal atrial fibrillation and paroxysmal supraventricular tachycardia.

4. Kidney transplantation: Cortiazem can be used after kidney transplantation to prevent graft rejection and reduce the nephrotoxicity of cyclosporine A.

Contraindications

Despite its effectiveness, Cortiazem has some contraindications, including:

1. Hypersensitivity to diltiazem or any other component of the drug.

2. Cardiogenic shock and severe left ventricular systolic dysfunction, including acute myocardial infarction.

3. Sinus arrhythmia, unless a permanent pacemaker is installed.

4. Atrioventricular block II-III degree (except for patients with a functioning artificial atrioventricular connection).

5. Acute heart failure.

6. Concomitant use of CYP3A4 inhibitors (eg, clarithromycin, itraconazole) or HIV proteinase inhibitors (eg, ritonavir).

Side effects

Cortiazem is generally well tolerated by patients, however some side effects may occur, including:

1. Dizziness and drowsiness.

2. Swelling of the limbs.

3. Bradycardia (slow heart rate).

4. Increased activity of liver enzymes.

5. Gastrointestinal disorders such as constipation or diarrhea.

6. Allergic reactions, including skin rash and itching.

Interaction with other drugs

Cortiazem may interact with some other medicines, so it is important to tell your doctor about all the medicines you are taking. Some known interactions include:

1. Antiarrhythmic drugs such as quinidine, amidarone and disopyramide. Cortiazem may enhance their effects and cause serious arrhythmias.

2. Drugs that inhibit the CYP3A4 enzyme, such as some antibiotics (erythromycin, clarithromycin) and antimycotics (ketoconazole, itraconazole). This may lead to increased concentrations of Cortiazem in the blood and increased side effects.

3. Drugs that induce the CYP3A4 enzyme, such as phenytoin and carbamazepine. They may reduce the concentration of Cortiazem in the blood and reduce its effectiveness.

4. Cyclosporine A. Cortiazem may increase the concentration of cyclosporine A in the blood, which requires monitoring its level and possible dose adjustment.

It is important to consult your doctor or pharmacist for more information about Cortiazem's interactions with other medications.

Conclusion

Cortiazem (diltiazem) is a calcium channel blocker used to treat cardiovascular diseases such as angina, hypertension, and heart rhythm disorders. It is effective and well tolerated, but may cause some side effects and