Curare-like Depolarizing Agents

Curare-like depolarizing agents is a group of drugs that are used in anesthesiology and surgery to relax muscles and reduce pain. They work by blocking nerve impulses, resulting in loss of muscle tone and decreased sensitivity to pain.

One of the most famous curare-like depolarizing agents is leptocurare. Leptocurare is a mixture of two substances: succinylcholine And pipecuronium bromide. Succinylcholine is a depolarizing muscle relaxant that blocks the transmission of nerve impulses in the muscles, causing them to relax. Pipecuronium bromide is also a depolarizing muscle relaxant, but it acts more slowly and has a longer half-life.

Leptocurare is used to prepare a patient for surgery or to administer anesthesia. It allows the surgeon to work freely on the patient without fear of the muscles contracting and causing pain or injury. In addition, leptocurare may be used to treat tetanus, where it is necessary to temporarily block nerve conduction to prevent seizures.

However, using leptocurare has its risks. In particular, it can cause serious side effects such as bradycardia, apnea, hypotension, hyperkalemia and arrhythmias. Also, when using leptocurare, it is necessary to monitor the level of residual neuromuscular conduction to avoid the development of complications.

Overall, leptocurare is an important tool in anesthesia practice. However, its use must be strictly controlled and supervised by an experienced anesthesiologist.

Curare-like drugs are toxic substances that block the transmission of nerve impulses. These substances lead to slow depolarization of nerve fibers. Due to their ability to have a curare-like effect and cause muscle paralysis, they are widely used in medicine. Thus, drugs containing benzoylcholine salts are used for anesthesia and general anesthesia in surgical practice. The following drugs have a curare-like effect:

Salaxan is a convulsive poison, inhibits the release of acetylcholine and activates peripheral cholinergic receptors, causing an increase in muscle tone and the appearance of neuromyoparalytic syndrome. It has a high affinity for motor neurons of the spinal cord. Depending on the dose, it may cause respiratory depression. Bemegride is similar to Corazol in its effect on central neurons. Reduces the excitability of the cerebral cortex and the tone of skeletal muscles, stimulates the activity of the cardiovascular system and liver. Used in drug treatment practice for the treatment of alcoholism.

Unlike curarin and succinylcholinotoquine drugs used in surgery, these drugs can cause reversible disorders of neuromuscular transmission or paralysis, but do not cause disturbances in the circulatory, respiratory and cardiovascular systems. Their anesthetic effect is lower than that of alkaloids, but higher than that of local anesthetics. Thus, the curare-like or anti-depolarizing effect of depolarization has many applications. They are used to keep patients immobilized before surgery to prevent bleeding or infection, and to treat paralysis of specific muscles and limbs.