Lipomatosis Multicentric

Multicentric lipomatosis is a syndrome that is a diffuse proliferation of several fat localizations in the body. This disease is dangerous due to the development of complications, and therefore requires timely diagnosis and treatment. The manifestation of pathology is associated with changes in metabolism

Lipomatosis is a disease or pathology of connective tissue of a dystrophic or hypotrophic nature, expressed in the formation of cysts and lipomas (a type of connective tissue cell cysts), mainly in middle-aged men. The cyst develops due to damage to the walls of blood vessels in the skin and subcutaneous tissue by lipocytes. Initially, this process occurs in the superficial layer of the skin, then passes into the subcutaneous fatty tissue. Not only the skin and subcutaneous tissue are affected, but also other parts of the body, including internal organs.

In medical practice, lipomatosis has several names: multicentric Tedeshi disease, Tedeshi lipomatosis, lipid storage disease. Local varieties of this disease are also distinguished, which distinguish the damage to one or another organ. Today it has been established that two types of fat storage are responsible for the development of this disease - glycerophosphate and cholesterol. They have different metabolic rates; with the same level of fat metabolism in people, different types predominate, and therefore lipomatosis develops in different organs. In adipose tissue there are structures - adenolipocytes, formed by the fusion of fat cells of subcutaneous structures with dermal cells.

The unusual name of the disease - lipomatosis - has nothing to do with adipose tissue, or rather, these are two incomparable things. It would be more correct to talk about an imbalance in the synthesis of substances in tissues, or about folds and diseases of the connective system. Since the first studies were carried out precisely in this area, the term “fat cells” and the substance fat were taken as a basis. Subsequently, they abandoned their use due to a mistake. Today there is no concept of lipomatosis, there are only lipomatous diseases. They are associated with disruption of the normal metabolism of connective tissues and metabolism in fat cells. If an extensive lipomatous process develops, which extends to all types of connective structures of the skin, it is called multicentric lipomatosis. The same process is formed in submucosal and subcutaneous fat accumulations. For example, multiple accumulations of fatty cell structures under the membranes of internal organs are called lipomatous disease, or visceral lipomatosis.