Lymphosarcoma

Lymphosarcoma is a group of malignant lymphoproliferative diseases arising from cells of lymphoid tissue.

There are two main forms of lymphosarcoma:

1. B-cell lymphosarcoma. They arise from B lymphocytes. May affect lymph nodes, spleen, bone marrow and other organs.

2. T-cell lymphosarcoma. Develop from T-lymphocytes. They are more often localized in the skin, less often in the lymph nodes and other organs.

Lymphosarcoma is characterized by infiltrative growth with invasion into surrounding tissues. Clinically manifested by enlarged lymph nodes, hepatosplenomegaly, and bone marrow damage.

Diagnosis is based on histological examination with the determination of immunohistochemical markers. Treatment includes chemotherapy, radiation therapy and, in some cases, surgery. The prognosis depends on the histological variant and stage of lymphosarcoma.