Sertoli-Leydig Cell Tumor

Tumors from Sertoli-Leydig cell lines

Sertoli-Lydig cell tumor, also known as arrhenoblatoma, is a rare tumor arising from interstitial Sertoli stem cells (stromal cells), which are the main structure of the testes. Tumors usually form from a subset of cells and are called mucinous or stromal cell tumors. Arrhenoblatomas are caused by uncontrolled growth, usually beneath the surface of the spermatic cord tissue. Arrenoblastoma is the second most common variant of Sertoli tumors after stromal tumor.

A small number of this type of tumor affects the testicles of men; in women they are rare and, as a rule, are asymptomatic. Primary diagnosis of arrheoblatoma involves routine testing of a complete blood count and urine count along with a blood test to detect male sex hormones during blood chemistry. Surgical removal is the gold standard for tumor treatment, which can be supplemented by radiation therapy. Although chemotherapy is rarely prescribed, if surgery is prescribed there is some hope for a complete cure. Despite aggressive diagnosis and treatment, in most cases no metastases are observed, although they occur even with surgical intervention.