Osteomyelofibrosis

Osteomyelosclerosis refers to various progressive pathologies of the bone marrow apparatus and bone tissue. The most common manifestation of the disease is osteosclerosis. The disease is characterized by the degeneration of functional bone marrow cells into fat and connective tissue. And the increased content of collagen in the affected area leads to the development of osteosclerosis, which occurs due to the impact of the disease itself or the pathology of hematopoietic stem cells.

Etiology of OMIF Main factors provoking the development of bone sclerosis in myelosclerosis: 1

Osteomyelitis is a chronic inflammatory disease of the bone marrow. In the initial stages, the disease occurs without symptoms, but over time, bone pain, bone destruction, fever and other signs of inflammation occur. A frequent complication of osteomyelitis is purulent lesions of the bone skeleton, requiring surgical intervention. Treatment is complex, including the use of antibiotics, anti-inflammatory drugs, decongestants, and immunomodulators.

Osteomyelitis is a nonspecific inflammation of the bone substance due to the penetration of a microbial agent into it - a pyogenic infection. There are osteoblastic and osteoclast forms of osteomyelitis, because each species is characterized by a specific bone condition. The main causative agent of osteomyelitis is pyogenic microbes from the group of strepto- and staphylococci, including streptostaphylococci and Staphylococcus aureus, less commonly Haemophilus influenzae, Escherichia coli, Proteus, anaerobes, and fungi; less often viruses. Microcarriage in osteomyelitis is transient in the first weeks after injury or surgery, which should be taken into account when diagnosing in the stage of inflammation resolution

Osteomyofibrosis is a rare type of leukemia. During the course of the disease, significant changes in bone tissue occur. The lesion is chronic and is accompanied by a severe outcome. At a later stage, with an increase in joint mass, the patient becomes inactive. Reasons for development:

● hereditary factor ● age 50-60 years ● pathologies of the liver, heart and lungs ● irradiation in the pelvic area and brain ● the effect of chemotherapy on the body ● hereditary predisposition Osteosclerosis can manifest itself systemically and locally. In the local form, damage to the joints and muscles occurs; in the systemic form, damage to the tubular bones in the legs and forearms develops. The process is divided into three phases:

1. Early. It is characterized by the appearance of pain in the bones without obvious changes in the joints. Muscle elasticity decreases, muscles increase in volume

2. Average. Soreness becomes constant, characteristic of the affected tissues. The mobility of the legs and arms is impaired. A person develops swelling of the knee and hip joints and has breathing problems

3. Late. The disease is characterized by an increase in leg length due to sprained ligaments, gait disturbance, and deformation of the limbs. Overgrowth of lung tissue occurs, affecting internal organs

Symptoms for osteosclerosis are almost the same in adults and children. Differences are observed only in the localization of pain zones. In young patients they are located around the sternum.

Osteodystrophic disease

*Osteomyelodysplasia* is a rare disease that manifests itself in the pathological growth of bone tissue and its modification, and also provokes abnormal processes in the formation of blood cells. Degenerative changes are accompanied by symptomatic bone loss. The disease is diagnosed during adulthood, mostly in women. Osteochondrosis is a condition in which tissue death in patients causes the development of a chronic course of diseases, characterized primarily by destructive changes with a low degree of negative impact on the patient’s immune system. **Complications of osteodystrophy**

The most dangerous consequences of this disease include:

1. increased blood pressure in the arteries of the brain; 2. myocardial infarction; 3. development of angina or arrhythmia; 4. pneumonia or pneumopleuritis; 5. psychosis or panic attacks.

The diagnosis of “osteochondrosis” will be made by an experienced