Phosphate-Diabetes

Phosphate diabetes: features of etiology, pathogenesis and treatment

Phosphate diabetes is a rare disease that is associated with profound disturbances in phosphorus-calcium metabolism in the body. It can be dominantly linked to the X chromosome or autosomal dominant. This disease cannot be restored by normal doses of vitamin D, so it is also known as vitamin D-resistant rickets, although in reality it is a rickets-like disease.

Etiology and pathogenesis of phosphate diabetes

It is assumed that in phosphate diabetes, the enzymatic processes of converting vitamin D into active hormone-like substances are disrupted. This may be caused by a decrease in the sensitivity of intestinal epithelial receptors to the action of these metabolites. Characteristic biochemical signs are phosphaturia, hypophosphatemia, increased function of the parathyroid glands and high activity of blood alkaline phosphatase. Reabsorption of calcium in the intestine is reduced.

Clinical picture of phosphate diabetes

Phosphate diabetes has similar features to ordinary D-deficient rickets, but differs from it in that with this disease there are no signs of intoxication, the general condition remains satisfactory. In contrast to rickets, the processes of osteomalacia and osteoid hyperplasia are expressed predominantly in the bones of the lower extremities.

Clinically, phosphate diabetes manifests itself not in the first months of life, but in the second half of life, after children begin to stand on their feet. The disease may also develop at a later age - in the 2nd year of life, sometimes at 5-6 years. Without treatment, the disease progresses as the child grows, which can lead to dystrophy and complete inability to move independently.

X-rays reveal the same changes that are characteristic of rickets, but the pathology is especially pronounced in the bones of the lower extremities. One of the typical radiological signs is the coarse fibrous structure of the cancellous bone.

Diagnosis of phosphate diabetes

Similar changes in the skeletal system can be detected in one of the parents, or the effect of the mutant gene in them can only be detected during a biochemical study. To diagnose phosphate diabetes, a biochemical blood test is necessary, which should include determination of the level of phosphorus, calcium, alkaline phosphatase, parathyroid hormone and vitamin D.

X-rays may show decreased bone density, changes in bone structure, and other signs of osteomalacia and osteoid hyperplasia.

Treatment of phosphate diabetes

Treatment of phosphate diabetes is aimed at correcting disturbances in phosphorus-calcium metabolism. The main drug is phosphate, which is introduced into the body intravenously or orally. Vitamin D in high doses can be used to improve phosphate absorption.

Supportive therapy is also provided, which includes physiotherapy, massage, therapeutic exercises, and the use of orthopedic products.

Prognosis of phosphate diabetes

The prognosis of phosphate diabetes depends on how early treatment is started and how effectively it is carried out. With timely and proper treatment, children with phosphate diabetes can achieve full development and live without significant limitations. However, if the disease is not treated, it can lead to severe degeneration and disability.

Phosphate diabetes: causes, symptoms and treatment

Phosphate diabetes, also known as phosphate diabetes, is a rare but serious disease associated with disturbances in the body's phosphorus metabolism. This condition is manifested by a decrease in the level of phosphate in the blood, which leads to uncontrolled

Phosphate diabetes is a serious disease that occurs as a result of an imbalance of phosphorus in the body. It is characterized by metabolic disorders and can lead to serious health consequences. In this article we will look at the causes of phosphate diabetes, its symptoms, diagnosis and treatment.

Causes of Phosphate Diabetes Phosphate diabetes can occur as a result of excess intake of phosphorus from food or medications. It can also be caused by a deficiency of calcium and magnesium, which are necessary for normal phosphorus metabolism.

Symptoms of Diabetes Phosphate The main symptoms of Diabetes Phosphate are:

- Bone and joint pain - Muscle weakness - Fatigue - Headaches - Increased thirst - Weight loss - Decreased appetite - Frequent urination

Diagnosis of phosphate diabetes is based on blood, urine and bone tests. X-rays or computed tomography may also be ordered to detect changes in bone tissue.

Phosphate treatment for diabetes includes changing your diet and increasing your intake of calcium and magnesium. In addition, medications may be prescribed to regulate phosphorus levels in the blood.

However, phosphate diabetes is a serious disease. Therefore, if you notice any symptoms, consult your doctor for diagnosis and treatment.