Proinsulin

**Proinsulin** is one of the most important proteins in the human body. It is a combination of proinsulin and co-crystallin molecules, which form a protein molecule together with a protein network of 5 types of proteins, the so-called proteoglycans.

**Proinsulinogenesis** occurs in pancreatic cells. During this process, glycosylation of proinsulin occurs through the N-terminal end by oarylamine transferases and fucosyltransferase present in the Golgi system. Proinsulin then enters the endoplasmic reticulum system, where it is glycosylated through the C-terminal part by amidylysine transferase and glycolysine transferase, and then transported to the outer capillary type of pancreatic tubules, where covalent binding of insulin to proinsulin occurs through