Atrophy Granular

Granular atrophy (angiomatosis granularis; synonym: granular angiomatosis) is a dermatological disease of unknown etiology, characterized by the formation of small red nodules and nodules on the skin. Pathomorphologically, this lesion appears to be a picture of angiomatosis (multiple capillaries, from which capillary hemangiomas can form) against the background of granulomatous tissue inflammation. Due to the predominance of vascularization over granulation of this

**Granular atrophy** is a gradual or rapid replacement of the parenchymal tissue of an organ with cystic fluid without changing the histoarchitecture of the functional class of the constituent functional zones. Does not have an inflammatory component.

**The mechanism of development** of granular atrophy depends on a combination of factors, among which the main role is played by the death of capillaries and the appearance in tissues of collagen breakdown products and other organic substances. In addition, the presence of atherosclerotic changes in the walls of blood vessels and microcirculation disorders is important. Also in the development of ADSS, an important role is played by damage to the hemostatic system with a decrease in the number of platelets and hypofibrinogenemia due to a decrease in the level of fibrinogen in the blood. Sometimes granular atrophy occurs only in one part of the parenchyma of an organ, without other degenerative processes in the organ. In the necrosis zone, cells are destroyed and the intercellular substance is removed, forming a boundary between healthy and necrotic tissues. If there are collaterals in the affected area through which blood supply continues, regeneration occurs, albeit slowly. Normal (not affected) tissue adapts to the consequences of decay and becomes more loose. It experiences an increase in microvascular permeability, its stability, and the growth of compensatory mechanisms during WGA over time and the development of compensatory regeneration decreases. As a result, replacement tissues gradually compress the structures of a healthy functioning organ. The fabric becomes dense and changes its appearance. An important difference between granular atrophy is the preservation of hyaline cells and nuclei, the nuclear structure in extensive lesions; a decrease in the interstitial tissue around the vessels and veins is detected. Cerebroplacental and angiopathy are not the cause of inflammation in the necrosis zone. They are characteristic of inflammatory and dystrophic changes in parenchymal tissues. In conclusion, I would like to note that granular atrophy is a fairly common pathological condition that can lead to irreversible changes in organ tissues.