Discoid Lupus Erythematosus (Dle)

Okay, I will write an article about Discoid Lupus Erythematosus, also known as Discoid Lupus Erythematosus (DLE).

Discoid lupus erythematosus (DLE) is a form of lupus erythematosus, an autoimmune disease that affects various human organs and tissues. DLE usually affects the skin by causing a characteristic rash pattern on the skin of round or oval red spots. These patches may be scaly or crusty and are usually found on the face, scalp, ears, neck and décolleté. DLE spots are often itchy and painful.

DLE can also affect other organs such as the joints, lungs, heart and kidneys, but this is less common than skin damage. In some cases, DLE can progress to systemic lupus, which can be life-threatening.

The causes of DLE are unknown, but genetic, environmental and immune factors are thought to play a role in its occurrence. The diagnosis of DLE is usually made based on clinical signs and skin biopsy. Treatment for DLE may include creams and ointments that reduce inflammation and itching, as well as anti-inflammatory and immunosuppressive medications.

Overall, DLE is a chronic condition that can greatly impact a patient's quality of life. It is important to receive regular treatment and monitor your health to prevent progression of the disease. If you have signs of DLE, contact your doctor for diagnosis and treatment.

Discoid lupus erythematosus is a rare chronic autoimmune disease of unknown etiology, which affects the connective tissue structures of the skin (cutaneous vasculitis). DLE causes painful, “hot,” pink, purple, or purplish-red spiky rashes (discoid lesions) that can develop into tumors. Atrophic scars are characteristic. The rash most often affects the face and proximal extremities. The lesions are described above, and a more detailed assessment of the condition of the skin will be given in the corresponding part of the article.

Provoking factors can be stress, injury, infection, vaccination, insolation, etc. Dispersed leprosy

Discoid lupus Red lupus erythematosus is the most serious variant of systemic lupus erythematosus. As the name suggests, it is characterized by the presence of red papules with ill-defined edges, tending to centrally scar. This disease is quite rare and accounts for 8-15% of cases of Lupus red. Photo from above.

- What are the causes of this pathology?

The causes are unknown. Although several genes are involved in this process causing an interaction between TGF-Beta and HLA-I class genes. There are various factors that can increase the risk of DLE, such as previous sunburn, older age or certain ethnic groups, however, there is an imbalance between genetic markers associated with increasing the risk of DLE and genetic factors that reduce it.

Most modern ideas about the pathogenesis of Discoid Lupus are based on the theory of autoimmune aggression, but there is no generally accepted mechanism. There are several theories. There are two main assumptions about the development of DLE: one is that it is an attack of self within the body, and the other is that the disease is caused by “super free radicals.” It is currently unclear whether this cell destruction induced by these free radicals is a process that begins before Disseminated Lupus is detected in patients, or whether it destroys the organ and causes the first characteristic sign only when the damage is complete.

The primary focus of the study of patients diagnosed with Discoid Lupus is on histopathological evidence of cellular dysregulation. Photos above. Identifying these changes requires a lot of experience, although it can be difficult in the early stages. Examples include microvasculature, disruption of compartmentalization, loss of endovascular mature macrophage pandimers, extracellular matrix damage, and neoangiogenesis. The latest research to visualize the changes is using a newly developed substance that can detect extracellular levels of MMP-2, an extracellular matrix-degrading enzyme that is implicated in many diseases.