Choriocarcinoma

Choriocarcinoma is a malignant tumor that develops from placental tissue. It belongs to germ cell tumors, as it arises from germinal epithelial cells.

Choriocarcinoma is characterized by rapid growth and early metastasis. The tumor consists of two types of cells - syncytiotrophoblasts and cytotrophoblasts. Syncytiotrophoblasts are responsible for the production of human chorionic gonadotropin, which is a marker of this disease.

Choriocarcinoma most often occurs after a normal or pathological pregnancy, less often after an ectopic pregnancy or abortion. Young age and first pregnancy are considered risk factors.

Diagnosis is based on determining the level of human chorionic gonadotropin and visualizing the tumor. The main treatment method is chemotherapy. The prognosis depends on the extent of the process; with early diagnosis, the 5-year survival rate reaches 90%.

- a type of cancer of the pregnant membrane, primarily of the fetal chorion. The most common malignant tumor of the testicle and placental origin. Ch. makes up about 4% of all malignant tumors of the female genital organs. The first mention of metastases from choriomelangioma (CM) in Sh. Yu. Reprev attributed to 638. There are indications of the disease in the 22nd century. There are 2 forms of CM - in male and female fetuses. According to pathomorphology, benign CM does not differ from malignant one, but according to histological properties they are distinguished into 3 groups. The first group includes chorion with many capillaries, hemorrhages, and without tumor tissue. The second group is the chorion, which contains a large number of cells fused into a solid mass. The third group consists of encapsulated round or elliptical tumors, solid or solid-cystic, surrounded by desmoplastic cell accumulations, with the presence of scars and myomatous areas.