Pustulosis Varioliform

Pustulosis varioliformis is a chronic recurrent skin disease characterized by the appearance on the skin of multiple pustules 2-5 mm in size, reminiscent of smallpox rashes.

The disease was first described in 1968 by the Hungarian dermatologist Pal Kaposi, therefore it is also called Kaposi varioliform rash, Kaposi syndrome or Kaposi pustulosis varioliformis.

The causes of the disease are not completely clear. Immunity disorders, infections, and genetic predisposition are thought to play a role in its development.

The disease manifests itself in the form of the sudden appearance on the skin of multiple pustules (pustules) with a diameter of 2-5 mm, surrounded by erythema. Pustules are localized mainly on the extensor surfaces of the limbs, trunk and face. Their number can vary from several to hundreds. The rash may be accompanied by itching and burning.

Diagnosis is based on the clinical picture and histological examination.

Treatment consists of prescribing antibiotics, immunosuppressants, retinoids, and ultraviolet radiation. The prognosis is favorable, but the disease has a tendency to relapse.

Pustulosis varioliformis is an inflammatory skin disease manifested by multiple flesh-colored blisters against the background of a hyperemic, edematous base. Pustulosis is characterized by remission and relapses; less commonly, with seborrheic and smallpox, generalization of the process occurs. Diagnosis is made based on examination of the skin and identification of etiological factors. Treatment includes the use of corticosteroids, antihistamines, and immunocorrectors. When the process spreads, nitrogenous drugs and bacteriophages can be used. Local application of medicinal substances reduces the duration of relapses and improves the quality of life of patients.