Serine phospholipids (synonyms: phosphatidylseroin, phosphatidissernoin) are phospholipids containing in their structure a serine residue or a serine-rich amino acid.
Serine phospholipids play important roles in cellular processes such as membrane signaling, regulation of enzyme activity, and lipid bilayer formation. Serine phospholipids can be synthesized both in the endoplasmic reticulum and in mitochondria.
Some of the more well-known serine phospholipids include phosphatidylsulfuric acid (PS), phosphatidylinositol (PI), phosphatidylactosylserine (PLS), and phosphatidyl oleate (PO).
PS and PLS are important components of biomembranes, participating in signaling through G protein-coupled receptors. PIS also plays a role in regulating the activity of enzymes such as the tricarboxylic acid cycle and pentose phosphate pathway enzymes.
PO is a major component of mitochondrial membranes, providing structural support and stability to mitochondria.
In general, serine phospholipids are an important component of cell membranes and are involved in various cellular processes.