Tolbutamide (Tolbutamide)

Tolbutamide is a medicinal substance used orally to treat non-insulin-dependent diabetes mellitus. Tolbutamide acts directly on the pancreas, stimulating insulin secretion; This drug is especially effective in elderly patients with moderate symptoms of diabetes (see Sulfonylurea). The side effects that may occur after taking tolbutamide are similar to those that occur with other sulfonamides; these include: allergic skin reactions and transient jaundice. Trade names: pramidex (Pramidcx), rastinon (Rastinon).

Tolbutamide plays a significant role in the treatment of insulin-independent diabetes mellitus, and it is used not only as monotherapy. However, already at the dawn of the use of the drug, its use caused numerous complaints among patients. The pronounced side effects of the drug were especially criticized - itching and jaundice caused by hypersensitivity, although they do not occur in every patient.

The first positive results in the therapeutic use of sulfonylureas were noted approximately 50 years ago. First, the drugs were administered subcutaneously in an insulin therapeutic dosage, then they were administered orally. Such long-term use had a high evidence base. At the beginning of the 20th century, researchers found more and more new methods of using these drugs. An interesting fact is that “sulfonyl”, as part of somatostatin, was an artificial hormone - a synthetic analogue of vasopressin, which created a certain dissonance between the endocrine and nervous systems. It was assumed that the hormonal effects of the drug could treat endocrine diseases. Scientists continue research to find optimal methods for administering these drugs at the present time.

**Tolbutamide** is a centrally acting hypoglycemic agent, a sulfonylurea derivative. By stimulating the release of glucagon-like peptide-1, it improves glucose-dependent insulin secretion... The pharmacological action of Tolbutomide is based on the direct effect of the drug on beta