Manufacturer country
UK, Glaxo UK, Glaxo Wellcome Italy, Glaxo Wellcome UK, Glaxo Operations UK UK
Pharm Group
Second generation cephalosporins
Manufacturers
Wellcome Ltd (UK), Glaxo (UK), Glaxo Wellcome (Italy), Glaxo Wellcome (UK), Glaxo Operations UK (UK)
International name
Cefuroxime
Synonyms
Axetin, Zinacef, Ketocef, Kefstar, Kefurox, Multisef, Novocef, Proxim, Supero, Ucefaxime, Cefogen, Cefuxime, Cefurabol, Cefuroxime sodium
Dosage forms
film-coated tablets 125mg, film-coated tablets 250mg, film-coated tablets 500mg, oral suspension 125mg/5ml, oral suspension 250mg, oral suspension, tablets 250mg, tablets 125mg, tablets 500mg, granulate for preparation
Compound
Active ingredient: Cefuroxime.
Indications for use
Infections of the upper and lower respiratory tract (acute and chronic bronchitis, infected bronchiectasis, pneumonia, lung abscess, pleural empyema), ear, throat and nose (otitis media, pharyngitis, tonsillitis, sinusitis), skin and soft tissues (erysipelas, cellulitis, pyoderma, impetigo, furunculosis), genitourinary tract (urethritis, acute and chronic pyelonephritis, cystitis, asymptomatic bacteriuria), joints, pelvic and abdominal organs, biliary tract and gastrointestinal tract, wound, gonorrhea (acute gonococcal urethritis and cervicitis), sepsis, bacterial septicemia , osteomyelitis, peritonitis, meningitis; prevention of infectious complications during operations.
Contraindications
Hypersensitivity (including to other cephalosporins, penicillins, carbapenems), bleeding and gastrointestinal diseases in the anamnesis, incl. nonspecific ulcerative colitis; pregnancy, breastfeeding.
Side effect
Diarrhea, nausea, vomiting, constipation, flatulence, abdominal cramps and pain, dyspepsia, oral ulcers, anorexia, thirst, oral candidiasis, glossitis, pseudomembranous colitis, transient increases in transaminases, alkaline phosphatase, LDH or bilirubin, liver dysfunction , cholestasis, impaired renal function, increased creatinine and/or urea nitrogen in the blood serum, decreased Cl creatinine, dysuria, itching in the perineum, vaginitis, chest pain, shortening of breathing, decreased hemoglobin and hematocrit, transient eosinophilia, neutropenia, leukopenia, aplastic and hemolytic anemia, thrombocytopenia, agranulocytosis, hypoprothrombinemia, prolongation of prothrombin time, headache, drowsiness, dysbiosis, superinfection, candidiasis, hearing impairment, convulsions (with renal failure), allergic reactions: rash, itching, urticaria; rarely - drug fever or chills, serum sickness, bronchospasm, positive Coombs test, erythema multiforme, interstitial nephritis, Stevens-Johnson syndrome and anaphylactic shock; local reactions: pain or infiltration at the injection site, thrombophlebitis after intravenous administration.
Interaction
Diuretics and nephrotoxic antibiotics increase the risk of kidney damage, and NSAIDs increase the risk of bleeding. Probenecid reduces tubular secretion, reduces renal Cl, increases Cmax, T1/2 and toxicity. Drugs that reduce stomach acidity may reduce the bioavailability of tablets.
Overdose
Symptoms: central nervous system stimulation, convulsions. Treatment: hemodialysis and peritoneal dialysis.
special instructions
With long-term use, it is recommended to monitor kidney function (especially when using high doses) and prevent dysbacteriosis. In patients with impaired renal function, the dose is reduced (taking into account