Arteritis Productive

Productive arteritis (PPA) is a rare disease characterized by the growth of abnormal tissue in the arterial walls. The growth occurs from the inner layer of the arterial wall - the intima. As a rule, arteries of medium and small diameter (arteries of the pulmonary circulation) are affected - aorta, bronchial, renal, coronary, central arteries of organs, large arteries of the head, neck and upper extremities.

The development of PPA is often caused by previous viral infections: syphilis, HIV, gonorrhea, rubella, ARVI, herpes virus infections, mononucleosis, adenoviral infection, viral hepatitis. In addition, obesity, hyperlipidemia, elevated levels of glycosylated hemoglobin, high doses of hormonal contraceptives, rheumatoid arthritis, myxedema, hypothyroidism, connective tissue diseases, immunosuppressive conditions, and heparin therapy may be a predisposing factor for the development of PPA. Pathological tissue proliferation can manifest itself as one large vessel (thromboembolism - involving the branches of the brain, bronchi, kidney vessels), or multiple lesions. With severe inflammation and damage to surrounding tissues, PPA can be accompanied by necrosis of the vascular wall, vascular thrombosis, narrowing of the lumen of the vascular trunk up to complete blockage, the formation of aneurysms and malformations of the muscles, esophagus, larynx and trachea. The development of PPA is associated with a wide range of extravasal manifestations: pulmonary hypertension, chronic interstitial and exudative pleurisy, pericarditis, systemic and pulmonary capillaropathy.