Coagulation Theory Narcosis

The coagulation theory of anesthesia (CTN) is a theory that explains anesthesia by a reversible change in the structure of proteins in the cytoplasm of neurons under the influence of narcotic substances such as ether, chloroform and barbiturates. According to this theory, drugs cause denaturation of proteins, which leads to a change in their conformation and disruption of functional activity.

Denaturation of proteins is a process in which a change in their three-dimensional structure occurs, which can lead to a loss of their functional activity. For example, proteins may lose their ability to bind to other proteins or to other molecules, which can cause disruption to the functioning of the cell or organism as a whole.

According to CTN, the effect of drugs on proteins leads to their denaturation, but this denaturation is reversible. After the cessation of the effect of the drugs, the proteins return to their normal conformation and functional activity is restored.

This theory was proposed in the early 20th century and has since become one of the most widely accepted theories of anesthesia. It explains why anesthesia causes loss of consciousness but does not cause permanent brain damage. In addition, CTN can help in the development of new methods of anesthesia that will be more effective and safe.

However, despite its popularity, CTN is not the only theory of anesthesia. There is also a theory of anesthesia, based on changes in the permeability of cell membranes, which also explains the effect of narcotic substances. In addition, there are other theories of anesthesia, such as the theory of changes in the activity of the nervous system or the theory of changes in metabolism.

In general, CTN is one of the most widespread theories of anesthesia and is still used in medicine to explain the effects of narcotic substances on the body. However, it is not the only correct theory and requires further study and development.

Coagulation theories of the origin of anesthesia can be divided into three groups:

* Excitation of coagulants (coagulants) between neurons without the formation of nervous tissue (old theory); * Coagulation mechanism (common to all coagulation theories). Protein denaturation in neurons under the influence of a coagulator causes loss of communication between them and dissociation of neurons with the formation of transparent radicular fluid. In this regard, a rearrangement of presynaptic terminals (axon hillocks and terminal branches of dendrites) of neighboring axons occurs, and contacts appear between the axonal endings of different neurons. These contacts quickly decrease and are replaced by cytoplasmic bridges of reduced glutathione, hydrogen peroxide and proteolytic enzymes; * Neurochemical basis. The use of anesthesia in them is final when studying the mechanism of action of each individual coagulant (amyl nitrite, acid