Acetyl-Coa

Acetyl-CoA is a coenzyme that is involved in the metabolism of carbohydrates, fats and proteins. It is formed as a result of a reaction catalyzed by acetyl-CoA synthetase, an enzyme of the lyase class. The synthesis of acetyl-CoA begins with a reaction between coenzyme A and acetic acid in the presence of ATP. As a result, acetyl-CoA is formed, and ATP is broken down into ADP and phosphate.

Acetyl-CoA is an important intermediate in the Krebs cycle, where it is oxidized to carbon dioxide and water. In addition, it is involved in the synthesis of fatty acids, cholesterol and ketone bodies. Lack of acetyl-CoA can lead to metabolic disorders, which can cause various diseases such as diabetes, obesity and other metabolic disorders.

The synthesis of acetyl-CoA occurs in the mitochondria of cells of the liver, kidneys, heart and other organs. This process is regulated by hormones such as insulin and glucagon, which control blood glucose levels. Acetyl-CoA also plays an important role in regulating the body's energy balance, as it is one of the main sources of energy for cells.

In general, acetyl-CoA and its synthesis are of great importance for the normal functioning of the body and maintaining its homeostasis. However, if this process is disrupted, it can lead to various diseases and metabolic disorders. Therefore, it is necessary to monitor the level of acetyl-CoA in the body and take measures to maintain it.

Acetyl coenzyme A (or acetoacetate, AcCoA for short) is an intermediate metabolite that is formed during the oxidation of ethanol (alcohol). Normally, after the oxidation of alcohol in the liver, one molecule of water is formed, which leaves the body, and the level of bicarbonates is restored. But if oxidation does not occur completely, then intermediate compounds appear that need to be removed. Other liver enzymes are involved in this - alcohol dehydrogenase, acetaldehyde dehydrogenase. Thus, acetyl derivatives are formed from this pair of enzymes, from which three molecules of acetate are produced by further catabolism, while the HCO3 molecule is converted into monosaccharides. Thus, 2 enzymes in the metabolism of Alcohol contribute to the elimination of products of alcohol metabolism: Alcohol dehydrogenase - acyl coenzyme. Acetaltadehedranase - coenzyme AOM, thiamine pyrophosphate. Acetone synthetase - Formed from aconite keto acids, Nitrogen-containing CDC - Cytaloplasmic isocitrate