Acroosteolysis Familial

Acroostolisis Family Acroosteolytic syndrome, acrostonic dysplasia, skeletal disease is a chronic multifactorial hereditary progressive dystrophic disease of the skeleton, characterized by a syndrome of weight loss with normal nutrition, loss of muscle tone and energy, multiple repeated spontaneous and usually painless injuries of the proximal limbs. The disease most often develops in females aged 5 to 20 years. Pathological changes characteristic of acroostolisis are also observed in other relatives. Clinical manifestations characterize a benign form of acroostiteal dystrophy. Acroostesis congenital basal necrotic osteodystrophy and Ipequan syndrome have been known since 1975 under the name acroostetolysis familial acroostalcytosis,